Design and synthesis of novel pyrrolo[2,1-c][1,4]benzodiazepine-imidazole containing polyamide conjugates

被引：0

作者：

Kumar, R ^{[1
]}

Reddy, BSN ^{[1
]}

Lown, JW ^{[1
]}

机构：

[1] Univ Alberta, Dept Chem, Edmonton, AB T6G 2G2, Canada

来源：

HETEROCYCLIC COMMUNICATIONS | 2002年 / 8卷 / 01期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel pyrrolo[2,1-c][1,4]benzodiazepine(PBD)-polyamide conjugates (1-5) containing imidazole units was synthesized as DNA minor groove bining agents.

引用

页码：19 / 26

页数：8

共 19 条

[11] STRUCTURE OF A COVALENT DNA MINOR-GROOVE ADDUCT WITH A PYRROLOBENZODIAZEPINE DIMER - EVIDENCE FOR SEQUENCE-SPECIFIC INTERSTRAND CROSS-LINKING [J].

JENKINS, TC ;

HURLEY, LH ;

NEIDLE, S ;

THURSTON, DE .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (26) :4529-4537

[12] STUDIES RELATED TO ANTI-TUMOR ANTIBIOTICS .16. MOLECULAR MECHANISM OF BINDING OF PYRROLO(1,4)BENZODIAZEPINE ANTI-TUMOR AGENTS TO DEOXYRIBONUCLEIC-ACID - ANTHRAMYCIN AND TOMAYMYCIN [J].

LOWN, JW ;

JOSHUA, AV .

BIOCHEMICAL PHARMACOLOGY, 1979, 28 (13) :2017-2026

[13] STRUCTURE AND SYNTHESIS OF NEOTHRAMYCIN [J].

MIYAMOTO, M ;

KONDO, S ;

NAGANAWA, H ;

MAEDA, K ;

OHNO, M ;

UMEZAWA, H .

JOURNAL OF ANTIBIOTICS, 1977, 30 (04) :340-343

[14]

RAO KE, 1992, TRENDS ORG CHEM, V3, P141

[15] Synthetic DNA minor groove-binding drugs [J].

Reddy, BSP ;

Sondhi, SM ;

Lown, JW .

PHARMACOLOGY & THERAPEUTICS, 1999, 84 (01) :1-111

[16]

Reddy BSP, 2000, ANTI-CANCER DRUG DES, V15, P225

[17]

REMERS W, 1988, ANTITUMOUR ANTIBIOTI, P28

[18]

Sondhi SM, 1997, CURR MED CHEM, V4, P313

[19]

Thurston D.E., 1993, MOL ASPECTS ANTICANC, P54

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