Quantitative Shear-Wave Elastography of the Liver in Preterm Neonates with Intra-Uterine Growth Restriction

被引:18
作者
Alison, Marianne [1 ,2 ,3 ]
Biran, Valerie [2 ,3 ,4 ,5 ]
Tanase, Anca [1 ,2 ,3 ]
Bendavid, Matthieu [2 ,4 ,5 ]
Blouet, Marie [1 ,2 ]
Demene, Charlie [3 ,6 ]
Sebag, Guy [1 ,2 ,3 ]
Tanter, Mickael [3 ,6 ]
Baud, Olivier [2 ,3 ,4 ,5 ]
机构
[1] Robert Debre Children Univ Hosp, Dept Pediat Radiol, F-75019 Paris, France
[2] Denis Diderot Paris Univ, APHP, F-75019 Paris, France
[3] PremUP Fdn, F-75014 Paris, France
[4] Robert Debre Children Univ Hosp, Neonatal Intens Care Unit, F-75019 Paris, France
[5] Robert Debre Children Univ Hosp, INSERM, U1141, F-75019 Paris, France
[6] ESPCI ParisTech, CNRS, UMR 7587, Inst Langevin,INSERM,U979, F-75005 Paris, France
来源
PLOS ONE | 2015年 / 10卷 / 11期
基金
欧洲研究理事会;
关键词
IMPULSE ARFI ELASTOGRAPHY; TRANSIENT ELASTOGRAPHY; HEPATITIS-B; BLOOD-FLOW; FIBROSIS; NUTRITION; CHOLESTASIS; STIFFNESS; OPERATION; DIAGNOSIS;
D O I
10.1371/journal.pone.0143220
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The feasibility and reproducibility of liver stiffness measurements using Supersonic Shear-wave Imaging (SSI) in preterm neonate have not been reported. Our aim was to determine if liver stiffness differs between intra-uterine growth restriction (IUGR) and appropriate for gestational age (AGA) preterm infants with/without cholestasis. We measured liver stiffness (in kPa) in 45 AGA and 18 IUGR preterm infants, and assessed reproducibility in 26 preterms using Intraclass Correlation Coefficients (ICC) and Bland-Altman tests. Liver stiffness values were compared between AGA and IUGR with and without cholestasis and correlated with birth weight. Measurements showed high reproducibility (ICC = 0.94-0.98 for intra-operator, 0.86 for inter-operator) with good agreement (95% limits: -1.24 to 1.24 kPa). During the first postnatal week, liver stiffness was higher in IUGR (7.50 +/- 1.53 kPa) than in AGA infants (5.11 +/- 0.80 kPa, p<0.001). After day 8, liver stiffness remained unchanged in AGA but increased progressively in IUGR infants (15.57 +/- 6.49 kPa after day 21). Liver stiffness was higher in IUGR neonates with cholestasis (19.35 +/- 9.80 kPa) than without cholestasis (7.72 +/- 1.27 kPa, p<0.001). In conclusion, quantitative liver SSI in preterms is feasible and reproducible. IUGR preterms who will develop cholestasis present high liver stiffness even at birth, before biological cholestasis occurs.
引用
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页数:14
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