Aminoglycoside array for the high-throughput analysis of small molecule-RNA interactions

被引：25
|
作者：
Bryan, MC
Wong, CH
机构：
[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 18期
关键词：
microarray; aminoglycoside; carbohydrate; RNA;
D O I：
10.1016/j.tetlet.2004.03.035
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Aminoglycoside-based oligosaccharides were bound to microtiter plates using noncovalent display with hybridization confirmed by mass spectrometry. Recognition of the saccharides by a model of the prokaryotic 16S aminoacyl site of the ribosomal decoding region was then determined. Tobramycin binding constants that correlated with surface plasmon resonance values for the model were effectively measured and novel means for binding aminoglycoside-based members were discovered for application to future aminoglycoside libraries. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3639 / 3642
页数：4
相关论文
共 50 条
  • [1] Small molecule-RNA interactions.
    Yan, ZH
    Baranger, AM
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2003, 226 : U199 - U199
  • [2] Systematic analysis of the interactions driving small molecule-RNA recognition
    Padroni, G.
    Patwardhan, N. N.
    Schapira, M.
    Hargrove, A. E.
    RSC MEDICINAL CHEMISTRY, 2020, 11 (07): : 802 - 813
  • [3] Conformationally constrained aminoglycoside analogues and the understanding of small molecule-RNA binding
    Zhao, F
    Blount, K
    Tor, Y
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 229 : U260 - U260
  • [4] Riboswitches as models for studying small molecule-RNA interactions
    Hammond, Ming
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 257
  • [5] PEARL-seq: A Photoaffinity Platform for the Analysis of Small Molecule-RNA Interactions
    Mukherjee, Herschel
    Blain, J. Craig
    Vandivier, Lee E.
    Chin, Donovan N.
    Friedman, Jessica E.
    Liu, Fei
    Maillet, Ashley
    Fang, Chao
    Kaplan, Jenifer B.
    Li, Jinxing
    Chenoweth, David M.
    Christensen, Allan Beck
    Petersen, Lars Kolster
    Hansen, Nils Jakob Vest
    Barrera, Luis
    Kubica, Neil
    Kumaravel, Gnanasambandam
    Petter, Jennifer C.
    ACS CHEMICAL BIOLOGY, 2020, 15 (09) : 2374 - 2381
  • [6] Modeling small Molecule-RNA interactions: Applications to HIV TARRNA
    Lang, PT
    Gomez-Pinto, I
    Smithson, D
    Guy, RK
    Kuntz, ID
    James, T
    FASEB JOURNAL, 2006, 20 (04): : A73 - A73
  • [7] Large-scale analysis of small molecule-RNA interactions using multiplexed RNA structure libraries
    Nagasawa, Ryosuke
    Onizuka, Kazumitsu
    Komatsu, Kaoru R.
    Miyashita, Emi
    Murase, Hirotaka
    Ojima, Kanna
    Ishikawa, Shunya
    Ozawa, Mamiko
    Saito, Hirohide
    Nagatsugi, Fumi
    COMMUNICATIONS CHEMISTRY, 2024, 7 (01):
  • [8] Using SHAPE-MaP to probe small molecule-RNA interactions
    Martin, Sarah
    Blankenship, Carson
    Rausch, Jason W.
    Sztuba-Solinska, Joanna
    METHODS, 2019, 167 : 105 - 116
  • [9] Inhibition of gene expression in human cells through small molecule-RNA interactions
    Hwang, S
    Tamilarasu, N
    Ryan, K
    Huq, I
    Richter, S
    Still, WC
    Rana, TM
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (23) : 12997 - 13002
  • [10] Small molecule-RNA targeting: starting with the fundamentals
    Hargrove, Amanda E.
    CHEMICAL COMMUNICATIONS, 2020, 56 (94) : 14744 - 14756
12345