Tissue ischemia worsens during hemodialysis in end-stage renal disease patients

被引:30
作者
Malik, Jan [1 ]
Kudlicka, Jaroslav [1 ]
Lachmanova, Jana [2 ]
Valerianova, Anna [1 ]
Rocinova, Katarina [2 ]
Bartkova, Magdalena [2 ]
Tesar, Vladimir [2 ]
机构
[1] Charles Univ Prague, Fac Med 1, Gen Univ Hosp, Dept Internal Med 3, Prague, Czech Republic
[2] Charles Univ Prague, Fac Med 1, Gen Univ Hosp, Dept Nephrol, Prague, Czech Republic
关键词
Cognitive deficit; Dementia; End-stage renal disease; Hand ischemia; Hemodialysis; CHRONIC KIDNEY-DISEASE; COGNITIVE IMPAIRMENT; DIALYSIS; OXYGENATION; DIAGNOSIS; VELOCITY; DECLINE;
D O I
10.5301/jva.5000630
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Background: Cognitive deficit is a common problem in end-stage renal disease (ESRD) patients. Ultrafiltration and hemodialysis lead to profound hemodynamic changes. The aim of this pilot study was to describe brain and hand oxygenation values in ESRD patients and their changes during hemodialysis. Methods: Twenty-seven patients treated by chronic hemodialysis and 17 controls patients of the same age were included in the study. Regional saturation of oxygen (SrO2) was measured at the brain frontal lobe and at the hand with dialysis access using the INVOS 5100C. In 17 of ESRD patients, SrO2 was also monitored throughout hemodialysis. Finger systolic blood pressure and basic hemodialysis and laboratory data were collected. Results: Dialysis patients had lower brain and also hand SrO2 values at rest (51.5 +/- 10.9 vs. 68 +/- 7%, p< 0.0001 and 55 +/- 16 vs. 66 +/- 8%, p = 0.03, respectively). Both values further decreased during the first 35 minutes of hemodialysis (brain SrO2 to 47 +/- 8%, p< 0.0001 and hand to 45 +/- 14%, p< 0.0001, respectively). The brain SrO2 decrease was related to the ultrafiltration rate, the hand SrO2 decrease to the finger pressure and to blood hemoglobin. Conclusions: Chronic dialysis patients suffer from tissue ischemia and that even worsens after the beginning of hemodialysis. This observation may contribute to the understanding of cognitive deficit etiology.
引用
收藏
页码:47 / 51
页数:5
相关论文
共 22 条
[1]   Intradialytic Blood Pressure Abnormalities: The Highs, The Lows and All That Lies Between [J].
Assimon, Magdalene M. ;
Flythe, Jennifer E. .
AMERICAN JOURNAL OF NEPHROLOGY, 2015, 42 (05) :337-350
[2]   Blood transfusions increase cerebral, splanchnic, and renal oxygenation in anemic preterm infants [J].
Dani, Carlo ;
Pratesi, Simone ;
Fontanelli, Giulia ;
Barp, Jacopo ;
Bertini, Giovanna .
TRANSFUSION, 2010, 50 (06) :1220-1226
[3]   Are there Neurological Consequences of Recurrent Intradialytic Hypotension? [J].
Eldehni, Mohamed Tarek ;
McIntyre, Christopher W. .
SEMINARS IN DIALYSIS, 2012, 25 (03) :253-256
[4]   Evaluation of Cerebral Oxygenation in Patients Undergoing Long-Term Hemodialysis [J].
Hoshino, Taro ;
Ookawara, Susumu ;
Goto, Sawako ;
Miyazawa, Haruhisa ;
Ito, Kiyonori ;
Ueda, Yuichiro ;
Kaku, Yoshio ;
Hirai, Keiji ;
Nabata, Aoi ;
Mori, Honami ;
Yoshida, Izumi ;
Tabei, Kaoru .
NEPHRON CLINICAL PRACTICE, 2014, 126 (01) :57-61
[5]   Factors Affecting Cerebral Oxygenation in Hemodialysis Patients: Cerebral Oxygenation Associates with pH, Hemodialysis Duration, Serum Albumin Concentration, and Diabetes Mellitus [J].
Ito, Kiyonori ;
Ookawara, Susumu ;
Ueda, Yuichiro ;
Goto, Sawako ;
Miyazawa, Haruhisa ;
Yamada, Hodaka ;
Kitano, Taisuke ;
Shindo, Mitsunobu ;
Kaku, Yoshio ;
Hirai, Keiji ;
Yoshida, Masashi ;
Hoshino, Taro ;
Nabata, Aoi ;
Mori, Honami ;
Yoshida, Izumi ;
Kakei, Masafumi ;
Tabei, Kaoru .
PLOS ONE, 2015, 10 (02)
[6]  
Kramer RS, 2009, ANN THORAC SURG, V87, P44
[7]   More precise diagnosis of access stenosis: ultrasonography versus angiography [J].
Kudlicka, Jaroslav ;
Kavan, Jan ;
Tuka, Vladimir ;
Malik, Jan .
JOURNAL OF VASCULAR ACCESS, 2012, 13 (03) :310-314
[8]   ARTERIAL OXYGEN-CONTENT AND AGE ARE DETERMINANTS OF MIDDLE CEREBRAL-ARTERY BLOOD-FLOW VELOCITY [J].
MACKO, RF ;
AMERISO, SF ;
AKMAL, M ;
PAGANINIHILL, A ;
MOHLER, JG ;
MASSRY, SG ;
MEISELMAN, HJ ;
FISHER, M .
STROKE, 1993, 24 (07) :1025-1028
[9]   Understanding the dialysis access steal syndrome. A review of the etiologies, diagnosis, prevention and treatment strategies [J].
Malik, J. ;
Tuka, V. ;
Kasalova, Z. ;
Chytilova, E. ;
Slavikova, M. ;
Clagett, P. ;
Davidson, I. ;
Dolmatch, B. ;
Nichols, D. ;
Gallieni, M. .
JOURNAL OF VASCULAR ACCESS, 2008, 9 (03) :155-166
[10]   Recurrent Circulatory Stress: The Dark Side of Dialysis [J].
McIntyre, Christopher W. .
SEMINARS IN DIALYSIS, 2010, 23 (05) :449-451