Albumin-conjugated Cadmium Sulfide Nanoparticles and their Interaction with KB Cells

被引：17

作者：

Selim, K. M. Kamruzzaman ^{[1
]}

Kang, Inn-Kyu ^{[1
]}

Guo, Haiqing ^{[2
]}

机构：

[1] Kyungpook Natl Univ, Dept Polymer Sci, Taegu 702701, South Korea

[2] Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China

来源：

MACROMOLECULAR RESEARCH | 2009年 / 17卷 / 06期

关键词：

cadmium sulfide nanoparticles; bovine serum albumin; biocompatibility; fluorescence intensity; SEMICONDUCTOR QUANTUM DOTS; BOVINE SERUM-ALBUMIN; CDS NANOPARTICLES; SURFACE MODIFICATION; AQUEOUS-SOLUTION; IN-VIVO; NANOCRYSTALS; PROTEIN; NANOCOMPOSITES;

D O I：

10.1007/BF03218881

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Cytotoxicity is a severe problem of cadmium sulfide nanoparticles (CSNPs) for use in biological systems. In the present study, mercaptoacetic acid-coated CSNPs were conjugated with bovine serum albumin (BSA) to improve biocompatibility. The surface properties of the CSNPs and albumin-conjugated CSNPs (ACSNPs) were characterized by XRD, UV, FTIR, EA, TEM and DLS. Human breast cancer cells (KB cells) were then cultured in the presence of the nanoparticles to evaluate the cytotoxicity of CSNPs and ACSNPs. Finally, the fluorescence intensity of the nanoparticles' aqueous solution was examined using a fluorescence spectrometer. The results showed that the cell compatibility and fluorescence intensity of ACSNPs were higher than those of CSNPs. The strongly luminescent features of the biocompatible ACSNPs are promising for use in biological fields such as cellular labeling, intracellular tracking and molecular imaging.

引用

页码：403 / 410

页数：8

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