Molecularly imprinted uniform-sized polymer-based stationary phase for naproxen

被引：30
作者：
Haginaka, J [1 ]
Takehira, H [1 ]
Hosoya, K [1 ]
Tanaka, N [1 ]
机构：
[1] KYOTO INST TECHNOL, DEPT POLYMER SCI & ENGN, SAKYO KU, KYOTO 606, JAPAN
来源：
CHEMISTRY LETTERS | 1997年 / 06期
关键词：
D O I：
10.1246/cl.1997.555
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A molecularly imprinted uniform-sized polymer-based stationary phase for (S)-naproxen has been prepared using 4-vinylpyridine and ethylenedimethacrylate as a host functional monomer and cross-linker, respectively. The imprinted polymer material could separate naproxen enantiomers with separation factor of 1.74. Further, the materials showed high selectivity for naproxen and moderate selectivity for other 2-arylpropionic acid derivatives. On the other hand, the imprinted polymer material showed little selectivity for other acidic, basic and neutral compounds.
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页码：555 / 556
页数：2
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