Context-Dependent Regulation of Type17 Immunity by Microbiota at the Intestinal Barrier

被引：8

作者：

Akuzum, Begum ^{[1
]}

Lee, June-Yong ^{[1
,2
,3
]}

机构：

[1] Yonsei Univ, Dept Microbiol & Immunol, Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea

[2] Yonsei Univ, Inst Immunol & Immunol Dis, Coll Med, Seoul 03722, South Korea

[3] Yonsei Univ, Coll Med, Brain Korea 21 Plus Project Med Sci, Seoul 03722, South Korea

来源：

IMMUNE NETWORK | 2022年 / 22卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

Type17; immunity; Intestinal microbiome; Intestinal barrier; Antigen presentation; Microbial metabolite; Inflammatory bowel diseases (IBDs); Colitis-associated cancer (CAC); ROR gamma t; INFLAMMATORY-BOWEL-DISEASE; ARYL-HYDROCARBON RECEPTOR; MHC CLASS-II; T-CELLS; DENDRITIC CELLS; GUT MICROBIOME; TH17; CELLS; INTERLEUKIN-17; RECEPTOR; ENTEROCOCCUS-FAECALIS; MONOCLONAL-ANTIBODY;

D O I：

10.4110/in.2022.22.e46

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T-helper-17 (Th17) cells and related IL-17-producing (type17) lymphocytes are abundant at the epithelial barrier. In response to bacterial and fungal infection, the signature cytokines IL17A/F and IL-22 mediate the antimicrobial immune response and contribute to wound healing of injured tissues. Despite their protective function, type17 lymphocytes are also responsible for various chronic inflammatory disorders, including inflammatory bowel disease (IBD) and colitis associated cancer (CAC). A deeper understanding of type17 regulatory mechanisms could ultimately lead to the discovery of therapeutic strategies for the treatment of chronic inflammatory disorders and the prevention of cancer. In this review, we discuss the current understanding of the development and function of type17 immune cells at the intestinal barrier, focusing on the impact of microbiota-immune interactions on intestinal barrier homeostasis and disease etiology.

引用

页数：25

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