The association between frailty and MRI features of cerebral small vessel disease

被引：39

作者：

Kant, Ilse M. J. ^{[1
,2
,3
]}

Mutsaerts, Henri J. M. M. ^{[2
,3
]}

van Montfort, Simone J. T. ^{[1
,2
]}

Jaarsma-Coes, Myriam G. ^{[4
]}

Witkamp, Theodoor D. ^{[2
,3
]}

Winterer, Georg ^{[5
,6
,7
,8
,9
,10
]}

Spies, Claudia D. ^{[7
,8
,9
,10
]}

Hendrikse, Jeroen ^{[2
,3
]}

Slooter, Arjen J. C. ^{[1
,2
]}

de Bresser, Jeroen ^{[2
,3
,4
]}

Armbruster, Franz Paul ^{[11
]}

Boecher, Axel ^{[11
]}

Boraschi, Diana ^{[12
]}

Borchers, Friedrich ^{[7
,8
,9
,10
]}

Della Camera, Giacomo ^{[12
]}

van Delien, Edwin ^{[22
,23
]}

Diehl, Ina ^{[11
]}

Dschietzig, Thomas Bernd ^{[11
]}

Feinkohl, Insa ^{[13
]}

Filmer, Ariane ^{[14
]}

Gallinat, Juergen ^{[15
]}

Hafen, Bettina ^{[11
]}

Hartmann, Katarina ^{[11
]}

Heidtke, Karsten ^{[16
]}

Helmschrode, Anja ^{[11
]}

Italiani, Paola ^{[12
]}

Ittermann, Bernd ^{[14
]}

Krause, Roland ^{[17
]}

Kronabel, Marion ^{[12
]}

Kuehn, Simone ^{[15
,18
]}

Lachmann, Gunnar ^{[7
,8
,9
,10
]}

Melillo, Daniela ^{[12
]}

Menon, David K. ^{[19
]}

Moreno-Lopez, Laura ^{[19
]}

Moergeli, Rudolf ^{[7
,8
,9
,10
]}

Nuernberg, Peter ^{[16
]}

Ofosu, Kwaku ^{[7
,8
,9
,10
]}

Olbert, Maria ^{[7
,8
,9
,10
]}

Pietzsch, Malte ^{[20
]}

Pischon, Tobias ^{[13
]}

Preller, Jacobus ^{[21
]}

Ruppert, Jana ^{[11
]}

Schneider, Reinhard ^{[17
]}

Stamatakis, Emmanuel A. ^{[19
]}

Weber, Simon ^{[20
]}

Weyer, Marius ^{[11
]}

Winzeck, Stefan ^{[14
]}

Wolf, Alissa ^{[7
,8
,9
,10
]}

Yeurek, Fatima ^{[7
,8
,9
,10
]}

Zacharias, Norman ^{[7
,8
,9
,10
]}

机构：

[1] Univ Utrecht, UMC Utrecht, Dept Intens Care Med, Heidelberglaan 100, Utrecht, Netherlands

[2] Univ Utrecht, UMC Utrecht, Brain Ctr Rudolf Magnus, Heidelberglaan 100, Utrecht, Netherlands

[3] Univ Utrecht, UMC Utrecht, Dept Radiol, Heidelberglaan 100, Utrecht, Netherlands

[4] Leiden Univ, Dept Radiol, Med Ctr, Leiden, Netherlands

[5] Charite Univ Med Berlin, ECRC, Berlin, Germany

[6] Pharmalmage Biomarker Solut GmbH, Berlin, Germany

[7] Charite Univ Med Berlin, CVK, CCM, Dept Anesthesiol & Operat Intens Care Med, Berlin, Germany

[8] Free Univ Berlin, Berlin, Germany

[9] Humboldt Univ, Berlin, Germany

[10] Berlin Inst Hlth, Berlin, Germany

[11] Immundiagnostik AG, Stubenwald Allee 8a, D-64625 Bensheim, Germany

[12] CNR, Inst Prot Biochem, Naples, Italy

[13] Max Delbruck Ctr Mol Med Helmholtz Assoc MDC, Mol Epidemiol Res Grp, Berlin, Germany

[14] Phys Tech Bundesanstalt PTB Braunschweig & Berlin, Braunschweig, Germany

[15] Univ Med Ctr, Clin & Policlin Psychiat & Psychotherapy, Hamburg, Germany

[16] ATLAS Biolabs GmbH, Berlin, Germany

[17] Univ Luxembourg, Luxembourg Ctr Syst Biomed, Luxembourg, Luxembourg

[18] Max Planck Inst Human Dev, Lise Meitner Grp Environm Neurosci, Berlin, Germany

[19] Univ Cambridge, Dept Med, Div Anaesthesia, Cambridge, England

[20] Cellogic GmbH, Niedstr 21, D-12159 Berlin, Germany

[21] Cambridge Univ Hosp NHS Trust, Addenbrookes Hosp, Cambridge, England

[22] Univ Utrecht, Univ Med Ctr Utrecht, Dept Psychiat, Utrecht, Netherlands

[23] Univ Utrecht, Univ Med Ctr Utrecht, UMC Utrecht Brain Ctr, Utrecht, Netherlands

来源：

SCIENTIFIC REPORTS | 2019年 / 9卷 / 1期

基金：

欧洲研究理事会;

关键词：

WHITE-MATTER HYPERINTENSITIES; MILD COGNITIVE IMPAIRMENT; OLDER-ADULTS; BLOOD-FLOW; PHYSICAL FRAILTY; DEPRESSION; RELIABILITY; VALIDITY; HEALTH; COHORT;

D O I：

10.1038/s41598-019-47731-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Frailty is a common syndrome in older individuals that is associated with poor cognitive outcome. The underlying brain correlates of frailty are unclear. The aim of this study was to investigate the association between frailty and MRI features of cerebral small vessel disease in a group of non-demented older individuals. We included 170 participants who were classified as frail (n = 30), pre-frail (n = 85) or non-frail (n = 55). The association of frailty and white matter hyperintensity volume and shape features, lacunar infarcts and cerebral perfusion was investigated by regression analyses adjusted for age and sex. Frail and pre-frail participants were older, more often female and showed higher white matter hyperintensity volume (0.69 [95%-CI 0.08 to 1.31], p = 0.03 respectively 0.43 [95%-CI: 0.04 to 0.82], p = 0.03) compared to non-frail participants. Frail participants showed a non-significant trend, and pre-frail participants showed a more complex shape of white matter hyperintensities (concavity index: 0.04 [95%-CI: 0.03 to 0.08], p = 0.03; fractal dimensions: 0.07 [95%-CI: 0.00 to 0.15], p = 0.05) compared to non-frail participants. No between group differences were found in gray matter perfusion or in the presence of lacunar infarcts. In conclusion, increased white matter hyperintensity volume and a more complex white matter hyperintensity shape may be structural brain correlates of the frailty phenotype.

引用

页数：9

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