Cytotoxic alkaloids motuporamines A-C: Synthesis and structural verification

被引：33

作者：

Goldring, WPD ^{[1
]}

Weiler, L ^{[1
]}

机构：

[1] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 09期

关键词：

D O I：

10.1021/ol991029e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The unusual structure and biological properties of the marine alkaloids motuporamines A-C, as well as the uncertainty as to the position of the olefin within the ring of motuporamine C, led us to synthesize these compounds. The strategy utilized the ring closing metathesis reaction to form the 14- and 15-membered rings and Michael addition and amidation chemistry to introduce the spermine-like unit, The syntheses, structure assignment verifications, and also the determination of the position of the olefin in motuporamine C are described.

引用

页码：1471 / 1473

页数：3

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