The Scent of Colorectal Cancer: Detection by Volatile Organic Compound Analysis

被引：56
作者：
de Boer, Nanne K. H. [1 ]
de Meij, Tim G. J. [2 ]
Oort, Frank A. [1 ]
Ben Larbi, Ilhame [1 ]
Mulder, Chris J. J. [1 ]
van Bodegraven, Adriaan A. [1 ]
van der Schee, Marc P. [3 ]
机构：
[1] Vrije Univ Amsterdam Med Ctr, Dept Gastroenterol & Hepatol, NL-1007 MB Amsterdam, Netherlands
[2] Vrije Univ Amsterdam Med Ctr, Dept Pediat Gastroenterol, NL-1007 MB Amsterdam, Netherlands
[3] Univ Amsterdam, Acad Med Ctr, Dept Pediat Pulmonol, NL-1105 AZ Amsterdam, Netherlands
来源：
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY | 2014年 / 12卷 / 07期
关键词：
Colorectal Cancer; Adenoma; Screening; Volatile Organic Compounds; Electronic Nose; Canine Scent; Flatography; FATTY LIVER-DISEASE; ELECTRONIC NOSE; DIAGNOSIS; BREATH; MICROBIOTA; PRINCIPLE; CHILDREN; PROOF; TOOL;
D O I：
10.1016/j.cgh.2014.05.005
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The overall metabolic state of an individual is reflected by emitted volatile organic compounds (VOCs), which are gaseous carbon-based chemicals. In this review, we will describe the potential of VOCs as fully noninvasive markers for the detection of neoplastic lesions of the colon. VOCs are detected by our sensory olfactory nerves and form the molecular basis for our sense of smell. As such, we emit our own individual odor fingerprint or so-called smellprint. This may change over time in response to any alteration in metabolism such as modifications caused by gastrointestinal infection, inflammation, external factors such as medication and diet, or development of neoplastic disease such as colorectal cancer. This means that analysis of VOCs can provide a fully noninvasive metabolomics biomarker profile that could be used as a diagnostic tool. Thus far, canine scent detection, gas chromatography-mass spectrometry, and electronic nose technologies allow for discrimination between patients with and without colorectal cancer and also its precursor (advanced adenoma) with promising accuracy. The challenge for future research is to identify specific biomarkers driving these signals. This enables the development of primed sensors tailored toward accurate identification of volatiles specific to colorectal cancer and adenomas. Such a technique may allow noninvasive monitoring of response to therapy and could revolutionize screening practices for colorectal cancer and potentially many other gastrointestinal diseases.
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收藏
页码：1085 / 1089
页数：5
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