Physiology Helps GWAS Take a Step Closer to Mechanism

被引：5

作者：

Frayling, Timothy M. ^{[1
]}

Hattersley, Andrew T. ^{[1
]}

机构：

[1] Univ Exeter, Sch Med, Exeter, Devon, England

来源：

DIABETES | 2014年 / 63卷 / 06期

基金：

英国惠康基金;

关键词：

GENOME-WIDE ASSOCIATION; BETA-CELL FUNCTION; TYPE-2; GLUCOSE; LOCI; PATHOPHYSIOLOGY; INSIGHTS; PROVIDES;

D O I：

10.2337/db14-0130

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：1836 / 1837

页数：2

共 15 条

[1] Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians [J].

Cho, Yoon Shin ;

Chen, Chien-Hsiun ;

Hu, Cheng ;

Long, Jirong ;

Ong, Rick Twee Hee ;

Sim, Xueling ;

Takeuchi, Fumihiko ;

Wu, Ying ;

Go, Min Jin ;

Yamauchi, Toshimasa ;

Chang, Yi-Cheng ;

Kwak, Soo Heon ;

Ma, Ronald C. W. ;

Yamamoto, Ken ;

Adair, Linda S. ;

Aung, Tin ;

Cai, Qiuyin ;

Chang, Li-Ching ;

Chen, Yuan-Tsong ;

Gao, Yutang ;

Hu, Frank B. ;

Kim, Hyung-Lae ;

Kim, Sangsoo ;

Kim, Young Jin ;

Lee, Jeannette Jen-Mai ;

Lee, Nanette R. ;

Li, Yun ;

Liu, Jian Jun ;

Lu, Wei ;

Nakamura, Jiro ;

Nakashima, Eitaro ;

Ng, Daniel Peng-Keat ;

Tay, Wan Ting ;

Tsai, Fuu-Jen ;

Wong, Tien Yin ;

Yokota, Mitsuhiro ;

Zheng, Wei ;

Zhang, Rong ;

Wang, Congrong ;

So, Wing Yee ;

Ohnaka, Keizo ;

Ikegami, Hiroshi ;

Hara, Kazuo ;

Cho, Young Min ;

Cho, Nam H. ;

Chang, Tien-Jyun ;

Bao, Yuqian ;

Hedman, Asa K. ;

Morris, Andrew P. ;

McCarthy, Mark I. .

NATURE GENETICS, 2012, 44 (01) :67-U97

[2] Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity [J].

Dimas, Antigone S. ;

Lagou, Vasiliki ;

Barker, Adam ;

Knowles, Joshua W. ;

Maegi, Reedik ;

Hivert, Marie-France ;

Benazzo, Andrea ;

Rybin, Denis ;

Jackson, Anne U. ;

Stringham, Heather M. ;

Song, Ci ;

Fischer-Rosinsky, Antje ;

Boesgaard, Trine Wellov ;

Grarup, Niels ;

Abbasi, Fahim A. ;

Assimes, Themistocles L. ;

Hao, Ke ;

Yang, Xia ;

Lecoeur, Cecile ;

Barroso, Ines ;

Bonnycastle, Lori L. ;

Boettcher, Yvonne ;

Bumpstead, Suzannah ;

Chines, Peter S. ;

Erdos, Michael R. ;

Graessler, Jurgen ;

Kovacs, Peter ;

Morken, Mario A. ;

Narisu, Narisu ;

Payne, Felicity ;

Stancakova, Alena ;

Swift, Amy J. ;

Toenjes, Anke ;

Bornstein, Stefan R. ;

Cauchi, Stephane ;

Froguel, Philippe ;

Meyre, David ;

Schwarz, Peter E. H. ;

Haering, Hans-Ulrich ;

Smith, Ulf ;

Boehnke, Michael ;

Bergman, Richard N. ;

Collins, Francis S. ;

Mohlke, Karen L. ;

Tuomilehto, Jaakko ;

Quertemous, Thomas ;

Lind, Lars ;

Hansen, Torben ;

Pedersen, Oluf ;

Walker, Mark .

DIABETES, 2014, 63 (06) :2158-2171

[3] New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk [J].

Dupuis, Josee ;

Langenberg, Claudia ;

Prokopenko, Inga ;

Saxena, Richa ;

Soranzo, Nicole ;

Jackson, Anne U. ;

Wheeler, Eleanor ;

Glazer, Nicole L. ;

Bouatia-Naji, Nabila ;

Gloyn, Anna L. ;

Lindgren, Cecilia M. ;

Magi, Reedik ;

Morris, Andrew P. ;

Randall, Joshua ;

Johnson, Toby ;

Elliott, Paul ;

Rybin, Denis ;

Thorleifsson, Gudmar ;

Steinthorsdottir, Valgerdur ;

Henneman, Peter ;

Grallert, Harald ;

Dehghan, Abbas ;

Hottenga, Jouke Jan ;

Franklin, Christopher S. ;

Navarro, Pau ;

Song, Kijoung ;

Goel, Anuj ;

Perry, John R. B. ;

Egan, Josephine M. ;

Lajunen, Taina ;

Grarup, Niels ;

Sparso, Thomas ;

Doney, Alex ;

Voight, Benjamin F. ;

Stringham, Heather M. ;

Li, Man ;

Kanoni, Stavroula ;

Shrader, Peter ;

Cavalcanti-Proenca, Christine ;

Kumari, Meena ;

Qi, Lu ;

Timpson, Nicholas J. ;

Gieger, Christian ;

Zabena, Carina ;

Rocheleau, Ghislain ;

Ingelsson, Erik ;

An, Ping ;

O'Connell, Jeffrey ;

Luan, Jian'an ;

Elliott, Amanda .

NATURE GENETICS, 2010, 42 (02) :105-U32

[4] Genome-wide association study identifies three novel loci for type 2 diabetes [J].

Hara, Kazuo ;

Fujita, Hayato ;

Johnson, Todd A. ;

Yamauchi, Toshimasa ;

Yasuda, Kazuki ;

Horikoshi, Momoko ;

Peng, Chen ;

Hu, Cheng ;

Ma, Ronald C. W. ;

Imamura, Minako ;

Iwata, Minoru ;

Tsunoda, Tatsuhiko ;

Morizono, Takashi ;

Shojima, Nobuhiro ;

So, Wing Yee ;

Leung, Ting Fan ;

Kwan, Patrick ;

Zhang, Rong ;

Wang, Jie ;

Yu, Weihui ;

Maegawa, Hiroshi ;

Hirose, Hiroshi ;

Kaku, Kohei ;

Ito, Chikako ;

Watada, Hirotaka ;

Tanaka, Yasushi ;

Tobe, Kazuyuki ;

Kashiwagi, Atsunori ;

Kawamori, Ryuzo ;

Jia, Weiping ;

Chan, Juliana C. N. ;

Teo, Yik Ying ;

Shyong, Tai E. ;

Kamatani, Naoyuki ;

Kubo, Michiaki ;

Maeda, Shiro ;

Kadowaki, Takashi .

HUMAN MOLECULAR GENETICS, 2014, 23 (01) :239-246

[5]

Ingelsson E, 2010, DIABETES, V59, P1266, DOI [10.2337/DB09-1568, 10.2337/db09-1568]

[6] Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci [J].

Kooner, Jaspal S. ;

Saleheen, Danish ;

Sim, Xueling ;

Sehmi, Joban ;

Zhang, Weihua ;

Frossard, Philippe ;

Been, Latonya F. ;

Chia, Kee-Seng ;

Dimas, Antigone S. ;

Hassanali, Neelam ;

Jafar, Tazeen ;

Jowett, Jeremy B. M. ;

Li, Xinzhong ;

Radha, Venkatesan ;

Rees, Simon D. ;

Takeuchi, Fumihiko ;

Young, Robin ;

Aung, Tin ;

Basit, Abdul ;

Chidambaram, Manickam ;

Das, Debashish ;

Grundberg, Elin ;

Hedman, Asa K. ;

Hydrie, Zafar I. ;

Islam, Muhammed ;

Khor, Chiea-Chuen ;

Kowlessur, Sudhir ;

Kristensen, Malene M. ;

Liju, Samuel ;

Lim, Wei-Yen ;

Matthews, David R. ;

Liu, Jianjun ;

Morris, Andrew P. ;

Nica, Alexandra C. ;

Pinidiyapathirage, Janani M. ;

Prokopenko, Inga ;

Rasheed, Asif ;

Samuel, Maria ;

Shah, Nabi ;

Shera, A. Samad ;

Small, Kerrin S. ;

Suo, Chen ;

Wickremasinghe, Ananda R. ;

Wong, Tien Yin ;

Yang, Mingyu ;

Zhang, Fan ;

Abecasis, Goncalo R. ;

Barnett, Anthony H. ;

Caulfield, Mark ;

Deloukas, Panos .

NATURE GENETICS, 2011, 43 (10) :984-U94

[7] Meal and oral glucose tests for assessment of β-cell function:: modeling analysis in normal subjects [J].

Mari, A ;

Schmitz, O ;

Gastaldelli, A ;

Oestergaard, T ;

Nyholm, B ;

Ferrannini, E .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2002, 283 (06) :E1159-E1166

[8] Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes [J].

Morris, Andrew P. ;

Voight, Benjamin F. ;

Teslovich, Tanya M. ;

Ferreira, Teresa ;

Segre, Ayellet V. ;

Steinthorsdottir, Valgerdur ;

Strawbridge, Rona J. ;

Khan, Hassan ;

Grallert, Harald ;

Mahajan, Anubha ;

Prokopenko, Inga ;

Kang, Hyun Min ;

Dina, Christian ;

Esko, Tonu ;

Fraser, Ross M. ;

Kanoni, Stavroula ;

Kumar, Ashish ;

Lagou, Vasiliki ;

Langenberg, Claudia ;

Luan, Jian'an ;

Lindgren, Cecilia M. ;

Mueller-Nurasyid, Martina ;

Pechlivanis, Sonali ;

Rayner, N. William ;

Scott, Laura J. ;

Wiltshire, Steven ;

Yengo, Loic ;

Kinnunen, Leena ;

Rossin, Elizabeth J. ;

Raychaudhuri, Soumya ;

Johnson, Andrew D. ;

Dimas, Antigone S. ;

Loos, Ruth J. F. ;

Vedantam, Sailaja ;

Chen, Han ;

Florez, Jose C. ;

Fox, Caroline ;

Liu, Ching-Ti ;

Rybin, Denis ;

Couper, David J. ;

Kao, Wen Hong L. ;

Li, Man ;

Cornelis, Marilyn C. ;

Kraft, Peter ;

Sun, Qi ;

van Dam, Rob M. ;

Stringham, Heather M. ;

Chines, Peter S. ;

Fischer, Krista ;

Fontanillas, Pierre .

NATURE GENETICS, 2012, 44 (09) :981-+

[9] Moving on from GWAS: Functional Studies on the G6PC2 Gene Implicated in the Regulation of Fasting Blood Glucose [J].

O'Brien, Richard M. .

CURRENT DIABETES REPORTS, 2013, 13 (06) :768-777

[10] Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants [J].

Pasquali, Lorenzo ;

Gaulton, Kyle J. ;

Rodriguez-Segui, Santiago A. ;

Mularoni, Loris ;

Miguel-Escalada, Irene ;

Akerman, Ildem ;

Tena, Juan J. ;

Moran, Ignasi ;

Gomez-Marin, Carlos ;

van de Bunt, Martijn ;

Ponsa-Cobas, Joan ;

Castro, Natalia ;

Nammo, Takao ;

Cebola, Ines ;

Garcia-Hurtado, Javier ;

Angel Maestro, Miguel ;

Pattou, Francois ;

Piemonti, Lorenzo ;

Berney, Thierry ;

Gloyn, Anna L. ;

Ravassard, Philippe ;

Luis Gomez-Skarmeta, Jose ;

Mueller, Ferenc ;

McCarthy, Mark I. ;

Ferrer, Jorge .

NATURE GENETICS, 2014, 46 (02) :136-+

← 1 2 →

共 15 条

[1] Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians [J].

Cho, Yoon Shin ;

Chen, Chien-Hsiun ;

Hu, Cheng ;

Long, Jirong ;

Ong, Rick Twee Hee ;

Sim, Xueling ;

Takeuchi, Fumihiko ;

Wu, Ying ;

Go, Min Jin ;

Yamauchi, Toshimasa ;

Chang, Yi-Cheng ;

Kwak, Soo Heon ;

Ma, Ronald C. W. ;

Yamamoto, Ken ;

Adair, Linda S. ;

Aung, Tin ;

Cai, Qiuyin ;

Chang, Li-Ching ;

Chen, Yuan-Tsong ;

Gao, Yutang ;

Hu, Frank B. ;

Kim, Hyung-Lae ;

Kim, Sangsoo ;

Kim, Young Jin ;

Lee, Jeannette Jen-Mai ;

Lee, Nanette R. ;

Li, Yun ;

Liu, Jian Jun ;

Lu, Wei ;

Nakamura, Jiro ;

Nakashima, Eitaro ;

Ng, Daniel Peng-Keat ;

Tay, Wan Ting ;

Tsai, Fuu-Jen ;

Wong, Tien Yin ;

Yokota, Mitsuhiro ;

Zheng, Wei ;

Zhang, Rong ;

Wang, Congrong ;

So, Wing Yee ;

Ohnaka, Keizo ;

Ikegami, Hiroshi ;

Hara, Kazuo ;

Cho, Young Min ;

Cho, Nam H. ;

Chang, Tien-Jyun ;

Bao, Yuqian ;

Hedman, Asa K. ;

Morris, Andrew P. ;

McCarthy, Mark I. .

NATURE GENETICS, 2012, 44 (01) :67-U97

[2] Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity [J].

Dimas, Antigone S. ;

Lagou, Vasiliki ;

Barker, Adam ;

Knowles, Joshua W. ;

Maegi, Reedik ;

Hivert, Marie-France ;

Benazzo, Andrea ;

Rybin, Denis ;

Jackson, Anne U. ;

Stringham, Heather M. ;

Song, Ci ;

Fischer-Rosinsky, Antje ;

Boesgaard, Trine Wellov ;

Grarup, Niels ;

Abbasi, Fahim A. ;

Assimes, Themistocles L. ;

Hao, Ke ;

Yang, Xia ;

Lecoeur, Cecile ;

Barroso, Ines ;

Bonnycastle, Lori L. ;

Boettcher, Yvonne ;

Bumpstead, Suzannah ;

Chines, Peter S. ;

Erdos, Michael R. ;

Graessler, Jurgen ;

Kovacs, Peter ;

Morken, Mario A. ;

Narisu, Narisu ;

Payne, Felicity ;

Stancakova, Alena ;

Swift, Amy J. ;

Toenjes, Anke ;

Bornstein, Stefan R. ;

Cauchi, Stephane ;

Froguel, Philippe ;

Meyre, David ;

Schwarz, Peter E. H. ;

Haering, Hans-Ulrich ;

Smith, Ulf ;

Boehnke, Michael ;

Bergman, Richard N. ;

Collins, Francis S. ;

Mohlke, Karen L. ;

Tuomilehto, Jaakko ;

Quertemous, Thomas ;

Lind, Lars ;

Hansen, Torben ;

Pedersen, Oluf ;

Walker, Mark .

DIABETES, 2014, 63 (06) :2158-2171

[3] New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk [J].

Dupuis, Josee ;

Langenberg, Claudia ;

Prokopenko, Inga ;

Saxena, Richa ;

Soranzo, Nicole ;

Jackson, Anne U. ;

Wheeler, Eleanor ;

Glazer, Nicole L. ;

Bouatia-Naji, Nabila ;

Gloyn, Anna L. ;

Lindgren, Cecilia M. ;

Magi, Reedik ;

Morris, Andrew P. ;

Randall, Joshua ;

Johnson, Toby ;

Elliott, Paul ;

Rybin, Denis ;

Thorleifsson, Gudmar ;

Steinthorsdottir, Valgerdur ;

Henneman, Peter ;

Grallert, Harald ;

Dehghan, Abbas ;

Hottenga, Jouke Jan ;

Franklin, Christopher S. ;

Navarro, Pau ;

Song, Kijoung ;

Goel, Anuj ;

Perry, John R. B. ;

Egan, Josephine M. ;

Lajunen, Taina ;

Grarup, Niels ;

Sparso, Thomas ;

Doney, Alex ;

Voight, Benjamin F. ;

Stringham, Heather M. ;

Li, Man ;

Kanoni, Stavroula ;

Shrader, Peter ;

Cavalcanti-Proenca, Christine ;

Kumari, Meena ;

Qi, Lu ;

Timpson, Nicholas J. ;

Gieger, Christian ;

Zabena, Carina ;

Rocheleau, Ghislain ;

Ingelsson, Erik ;

An, Ping ;

O'Connell, Jeffrey ;

Luan, Jian'an ;

Elliott, Amanda .

NATURE GENETICS, 2010, 42 (02) :105-U32

[4] Genome-wide association study identifies three novel loci for type 2 diabetes [J].

Hara, Kazuo ;

Fujita, Hayato ;

Johnson, Todd A. ;

Yamauchi, Toshimasa ;

Yasuda, Kazuki ;

Horikoshi, Momoko ;

Peng, Chen ;

Hu, Cheng ;

Ma, Ronald C. W. ;

Imamura, Minako ;

Iwata, Minoru ;

Tsunoda, Tatsuhiko ;

Morizono, Takashi ;

Shojima, Nobuhiro ;

So, Wing Yee ;

Leung, Ting Fan ;

Kwan, Patrick ;

Zhang, Rong ;

Wang, Jie ;

Yu, Weihui ;

Maegawa, Hiroshi ;

Hirose, Hiroshi ;

Kaku, Kohei ;

Ito, Chikako ;

Watada, Hirotaka ;

Tanaka, Yasushi ;

Tobe, Kazuyuki ;

Kashiwagi, Atsunori ;

Kawamori, Ryuzo ;

Jia, Weiping ;

Chan, Juliana C. N. ;

Teo, Yik Ying ;

Shyong, Tai E. ;

Kamatani, Naoyuki ;

Kubo, Michiaki ;

Maeda, Shiro ;

Kadowaki, Takashi .

HUMAN MOLECULAR GENETICS, 2014, 23 (01) :239-246

[5]

Ingelsson E, 2010, DIABETES, V59, P1266, DOI [10.2337/DB09-1568, 10.2337/db09-1568]

[6] Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci [J].

Kooner, Jaspal S. ;

Saleheen, Danish ;

Sim, Xueling ;

Sehmi, Joban ;

Zhang, Weihua ;

Frossard, Philippe ;

Been, Latonya F. ;

Chia, Kee-Seng ;

Dimas, Antigone S. ;

Hassanali, Neelam ;

Jafar, Tazeen ;

Jowett, Jeremy B. M. ;

Li, Xinzhong ;

Radha, Venkatesan ;

Rees, Simon D. ;

Takeuchi, Fumihiko ;

Young, Robin ;

Aung, Tin ;

Basit, Abdul ;

Chidambaram, Manickam ;

Das, Debashish ;

Grundberg, Elin ;

Hedman, Asa K. ;

Hydrie, Zafar I. ;

Islam, Muhammed ;

Khor, Chiea-Chuen ;

Kowlessur, Sudhir ;

Kristensen, Malene M. ;

Liju, Samuel ;

Lim, Wei-Yen ;

Matthews, David R. ;

Liu, Jianjun ;

Morris, Andrew P. ;

Nica, Alexandra C. ;

Pinidiyapathirage, Janani M. ;

Prokopenko, Inga ;

Rasheed, Asif ;

Samuel, Maria ;

Shah, Nabi ;

Shera, A. Samad ;

Small, Kerrin S. ;

Suo, Chen ;

Wickremasinghe, Ananda R. ;

Wong, Tien Yin ;

Yang, Mingyu ;

Zhang, Fan ;

Abecasis, Goncalo R. ;

Barnett, Anthony H. ;

Caulfield, Mark ;

Deloukas, Panos .

NATURE GENETICS, 2011, 43 (10) :984-U94

[7] Meal and oral glucose tests for assessment of β-cell function:: modeling analysis in normal subjects [J].

Mari, A ;

Schmitz, O ;

Gastaldelli, A ;

Oestergaard, T ;

Nyholm, B ;

Ferrannini, E .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2002, 283 (06) :E1159-E1166

[8] Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes [J].

Morris, Andrew P. ;

Voight, Benjamin F. ;

Teslovich, Tanya M. ;

Ferreira, Teresa ;

Segre, Ayellet V. ;

Steinthorsdottir, Valgerdur ;

Strawbridge, Rona J. ;

Khan, Hassan ;

Grallert, Harald ;

Mahajan, Anubha ;

Prokopenko, Inga ;

Kang, Hyun Min ;

Dina, Christian ;

Esko, Tonu ;

Fraser, Ross M. ;

Kanoni, Stavroula ;

Kumar, Ashish ;

Lagou, Vasiliki ;

Langenberg, Claudia ;

Luan, Jian'an ;

Lindgren, Cecilia M. ;

Mueller-Nurasyid, Martina ;

Pechlivanis, Sonali ;

Rayner, N. William ;

Scott, Laura J. ;

Wiltshire, Steven ;

Yengo, Loic ;

Kinnunen, Leena ;

Rossin, Elizabeth J. ;

Raychaudhuri, Soumya ;

Johnson, Andrew D. ;

Dimas, Antigone S. ;

Loos, Ruth J. F. ;

Vedantam, Sailaja ;

Chen, Han ;

Florez, Jose C. ;

Fox, Caroline ;

Liu, Ching-Ti ;

Rybin, Denis ;

Couper, David J. ;

Kao, Wen Hong L. ;

Li, Man ;

Cornelis, Marilyn C. ;

Kraft, Peter ;

Sun, Qi ;

van Dam, Rob M. ;

Stringham, Heather M. ;

Chines, Peter S. ;

Fischer, Krista ;

Fontanillas, Pierre .

NATURE GENETICS, 2012, 44 (09) :981-+

[9] Moving on from GWAS: Functional Studies on the G6PC2 Gene Implicated in the Regulation of Fasting Blood Glucose [J].

O'Brien, Richard M. .

CURRENT DIABETES REPORTS, 2013, 13 (06) :768-777

[10] Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants [J].

Pasquali, Lorenzo ;

Gaulton, Kyle J. ;

Rodriguez-Segui, Santiago A. ;

Mularoni, Loris ;

Miguel-Escalada, Irene ;

Akerman, Ildem ;

Tena, Juan J. ;

Moran, Ignasi ;

Gomez-Marin, Carlos ;

van de Bunt, Martijn ;

Ponsa-Cobas, Joan ;

Castro, Natalia ;

Nammo, Takao ;

Cebola, Ines ;

Garcia-Hurtado, Javier ;

Angel Maestro, Miguel ;

Pattou, Francois ;

Piemonti, Lorenzo ;

Berney, Thierry ;

Gloyn, Anna L. ;

Ravassard, Philippe ;

Luis Gomez-Skarmeta, Jose ;

Mueller, Ferenc ;

McCarthy, Mark I. ;

Ferrer, Jorge .

NATURE GENETICS, 2014, 46 (02) :136-+

← 1 2 →