Causal Link between the Cortico-Rubral Pathway and Functional Recovery through Forced Impaired Limb Use in Rats with Stroke

被引：73

作者：

Ishida, Akimasa ^{[1
,2
]}

Isa, Kaoru ^{[2
]}

Umeda, Tatsuya ^{[2
]}

Kobayashi, Kazuto ^{[3
]}

Kobayashi, Kenta ^{[4
,5
]}

Hida, Hideki ^{[1
]}

Isa, Tadashi ^{[2
,5
]}

机构：

[1] Nagoya City Univ, Grad Sch Med Sci, Dept Neurophysiol & Brain Sci, Nagoya, Aichi 4678601, Japan

[2] Natl Inst Nat Sci, Dept Dev Physiol, Okazaki, Aichi 4448585, Japan

[3] Fukushima Med Univ, Dept Mol Genet, Inst Biomed Sci, Fukushima 9601295, Japan

[4] Natl Inst Physiol Sci, Sect Viral Vector Dev, Okazaki, Aichi 4448585, Japan

[5] Grad Univ Adv Studies SOKENDAI, Hayama 2400193, Japan

来源：

JOURNAL OF NEUROSCIENCE | 2016年 / 36卷 / 02期

关键词：

forced limb use; intracerebral hemorrhage; red nucleus; rehabilitation; reorganization; use-dependent plasticity; INDUCED MOVEMENT THERAPY; SPINAL-CORD-INJURY; MOTOR CORTEX; SENSORIMOTOR CORTEX; LOCOMOTOR RECOVERY; RUBROSPINAL TRACT; INTERNAL CAPSULE; SMALL HEMORRHAGE; PREMOTOR CORTEX; RED NUCLEUS;

D O I：

10.1523/JNEUROSCI.2399-15.2016

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intensive rehabilitation is believed to induce use-dependent plasticity in the injured nervous system; however, its causal relationship to functional recovery is unclear. Here, we performed systematic analysis of the effects of forced use of an impaired forelimb on the recovery of rats after lesioning the internal capsule with intracerebral hemorrhage (ICH). Forced limb use (FLU) group rats exhibited better recovery of skilled forelimb functions and their cortical motor area with forelimb representation was restored and enlarged on the ipsilesional side. In addition, abundant axonal sprouting from the reemerged forelimb area was found in the ipsilateral red nucleus after FLU. To test the causal relationship between the plasticity in the cortico-rubral pathway and recovery, loss-of-function experiments were conducted using a double-viral vector technique, which induces selective blockade of the target pathway. Blockade of the cortico-rubral tract resulted in deficits of the recovered forelimb function in FLU group rats. These findings suggest that the cortico-rubral pathway is a substrate for recovery induced by intensive rehabilitation after ICH.

引用

页码：455 / 467

页数：13

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