Simple procedure for preparation of α-fluoro esters by fluorination of ester enol silyl ethers with perchloryl fluoride

被引：12

作者：

Fujisawa, H ^{[1
]}

Takeuchi, Y ^{[1
]}

机构：

[1] Toyama Med & Pharmaceut Univ, Fac Pharmaceut Sci, Toyama 9300194, Japan

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2002年 / 117卷 / 02期

关键词：

alpha-fluoro ester; perchloryl fluoride; ester enol silyl ether;

D O I：

10.1016/S0022-1139(02)00185-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Fluorination of ester enol silyl ethers in THF at room temperature using diluted perchloryl fluoride (FClO3) in the presence of ca. 0.5 M eq. of t-BuNH2 as an additive produced the corresponding alpha-fluoro esters in over 80% yields. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：173 / 176

页数：4

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