Establishing risk of human experimentation with drugs: lessons from TGN1412

被引:103
作者
Kenter, M. J. H.
Cohen, A. F.
机构
[1] CHDR, NL-2333 CL Leiden, Netherlands
[2] Cent Comm Res Invilving Human Subjects, The Hague, Netherlands
关键词
D O I
10.1016/S0140-6736(06)69562-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1387 / 1391
页数:5
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共 30 条
[1]   Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].
Altschul, SF ;
Madden, TL ;
Schaffer, AA ;
Zhang, JH ;
Zhang, Z ;
Miller, W ;
Lipman, DJ .
NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3389-3402
[2]   Co-stimulatory agonists as immunological adjuvants [J].
Barr, TA ;
Carring, J ;
Heath, AW .
VACCINE, 2006, 24 (17) :3399-3407
[3]   Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4 [J].
Beck, Kimberly E. ;
Blansfield, Joseph A. ;
Tran, Khoi Q. ;
Feldman, Andrew L. ;
Hughes, Marybeth S. ;
Royal, Richard E. ;
Kammula, Udai S. ;
Topalian, Suzanne L. ;
Sherry, Richard M. ;
Kleiner, David ;
Quezado, Martha ;
Lowy, Israel ;
Yellin, Michael ;
Rosenberg, Steven A. ;
Yang, James C. .
JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (15) :2283-2289
[4]   TGN1412: Time to change the paradigm for the testing of new pharmaceuticals [J].
Bhogal, Nirmala ;
Combes, Robert .
ATLA-ALTERNATIVES TO LABORATORY ANIMALS, 2006, 34 (02) :225-239
[5]   Cytotoxic T-Lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer [J].
Blansfield, JA ;
Beck, KE ;
Tran, K ;
Yang, DC ;
Hughes, MS ;
Kammula, US ;
Royal, RE ;
Topalian, SL ;
Haworth, LR ;
Levy, C ;
Rosenberg, SA ;
Sherry, RM .
JOURNAL OF IMMUNOTHERAPY, 2005, 28 (06) :593-598
[6]   New SEC regulations could hinder biotech investment [J].
Bouchie, A .
NATURE BIOTECHNOLOGY, 2002, 20 (07) :639-640
[7]   Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial [J].
Bresalier, RS ;
Sandler, RS ;
Quan, H ;
Bolognese, JA ;
Oxenius, B ;
Horgan, K ;
Lines, C ;
Riddell, R ;
Morton, D ;
Lanas, A ;
Konstam, MA ;
Baron, JA .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (11) :1092-1102
[8]   A death in the laboratory: The politics of the Gelsinger aftermath [J].
Carmen, IH .
MOLECULAR THERAPY, 2001, 3 (04) :425-428
[9]   Non-Fc receptor-binding humanized anti-CD3 antibodies induce apoptosis of activated human T cells [J].
Carpenter, PA ;
Pavlovic, S ;
Tso, JY ;
Press, OW ;
Gooley, T ;
Yu, XZ ;
Anasetti, C .
JOURNAL OF IMMUNOLOGY, 2000, 165 (11) :6205-6213
[10]   Non-FcR-binding, humanized anti-CD3 antibody Hu291 induces apoptosis of human T cells more effectively than OKT3 and is immunosuppressive in vivo [J].
Carpenter, PA ;
Tso, JY ;
Press, OW ;
Yu, XZ ;
Anasetti, C .
TRANSPLANTATION PROCEEDINGS, 2000, 32 (07) :1545-1546