Biology of Acinetobacter baumannii: Pathogenesis, Antibiotic Resistance Mechanisms, and Prospective Treatment Options

被引：695

作者：

Lee, Chang-Ro ^{[1
]}

Lee, Jung Hun ^{[1
]}

Park, Moonhee ^{[1
,2
]}

Park, Kwang Seung ^{[1
]}

Bae, Il Kwon ^{[3
]}

Kim, Young Bae ^{[4
]}

Cha, Chang-Jun ^{[5
]}

Jeong, Byeong Chul

Lee, Sang Hee ^{[1
]}

机构：

[1] Myongji Univ, Dept Biol Sci, Natl Leading Res Lab Drug Resistance Prote, Yongin, South Korea

[2] Natl Forens Serv, DNA Anal Div, Seoul, South Korea

[3] Silla Univ, Dept Dent Hyg, Coll Hlth & Welf, Busan, South Korea

[4] North Shore Community Coll, Biotechnol Program, Danvers, MA USA

[5] Chung Ang Univ, Dept Syst Biotechnol, Coll Biotechnol & Nat Resources, Anseong, South Korea

来源：

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2017年 / 7卷

基金：

新加坡国家研究基金会;

关键词：

antimicrobial resistance; Acinetobacter baumannii; treatment option; resistance mechanism; virulence factor; OUTER-MEMBRANE PROTEIN; IN-VITRO ACTIVITY; METALLO-BETA-LACTAMASE; VI SECRETION SYSTEM; CARBAPENEM-HYDROLYZING OXACILLINASES; K1 CAPSULAR POLYSACCHARIDE; GENOME SEQUENCE-ANALYSIS; CRITICALLY-ILL PATIENTS; MULTIDRUG EFFLUX PUMP; INTENSIVE-CARE UNITS;

D O I：

10.3389/fcimb.2017.00055

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Acinetobacter baumannii is undoubtedly one of the most successful pathogens responsible for hospital-acquired nosocomial infections in the modern healthcare system. Due to the prevalence of infections and outbreaks caused by multi-drug resistant A. baumannii, few antibiotics are effective for treating infections caused by this pathogen. To overcome this problem, knowledge of the pathogenesis and antibiotic resistance mechanisms of A. baumannii is important. In this review, we summarize current studies on the virulence factors that contribute to A. baumannii pathogenesis, including porins, capsular polysaccharides, lipopolysaccharides, phospholipases, outer membrane vesicles, metal acquisition systems, and protein secretion systems. Mechanisms of antibiotic resistance of this organism, including acquirement of beta-lactamases, up-regulation of multidrug efflux pumps, modification of aminoglycosides, permeability defects, and alteration of target sites, are also discussed. Lastly, novel prospective treatment options for infections caused by multi-drug resistant A. baumannii are summarized.

引用

页数：35

共 444 条

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