Clinical Characteristics and Treatment Outcomes in Children, Adolescents, and Young-adults with Hodgkin's Lymphoma: a KPHOG Lymphoma Working-party, Multicenter, Retrospective Study

被引：2

作者：

Lee, Jae Min ^{[1
]}

Choi, Jung Yoon ^{[2
,3
]}

Hong, Kyung Taek ^{[2
,3
]}

Kang, Hyoung Jin ^{[2
,3
]}

Shin, Hee Young ^{[2
,3
]}

Baek, Hee Jo ^{[4
]}

Kook, Hoon ^{[4
]}

Kim, Seongkoo ^{[5
]}

Lee, Jae Wook ^{[5
]}

Chung, Nack-Gyun ^{[5
]}

Cho, Bin ^{[5
]}

Cho, Seok-Goo ^{[6
]}

Park, Kyung Mi ^{[7
]}

Yang, Eu Jeen ^{[7
]}

Lim, Young Tak ^{[7
]}

Suh, Jin Kyung ^{[8
]}

Kang, Sung Han ^{[8
]}

Kim, Hyery ^{[8
]}

Koh, Kyung-Nam ^{[8
]}

Im, Ho Joon ^{[8
]}

Seo, Jong Jin ^{[8
]}

Cho, Hee Won ^{[9
]}

Ju, Hee Young ^{[9
]}

Lee, Ji Won ^{[9
]}

Yoo, Keon Hee ^{[9
]}

Sung, Ki Woong ^{[9
]}

Koo, Hong Hoe ^{[9
]}

Park, Kyung Duk ^{[10
,11
]}

Hah, Jeong Ok ^{[12
]}

Kim, Min Kyoung ^{[13
]}

Han, Jung Woo ^{[14
]}

Hahn, Seung Min ^{[14
]}

Lyu, Chuhl Joo ^{[14
]}

Shim, Ye Jee ^{[15
]}

Kim, Heung Sik ^{[15
]}

Do, Young Rok ^{[16
]}

Yoo, Jae Won ^{[17
]}

Lim, Yeon Jung ^{[17
]}

Jeon, In-Sang ^{[18
]}

Chueh, Hee Won ^{[19
]}

Oh, Sung Yong ^{[20
]}

Choi, Hyoung Soo ^{[21
]}

Park, Jun Eun ^{[22
]}

Lee, Jun Ah ^{[23
]}

Park, Hyeon Jin ^{[23
]}

Park, Byung-Kiu ^{[23
]}

Kim, Soon Ki ^{[24
]}

Lim, Jae Young ^{[25
]}

Park, Eun Sil ^{[25
]}

Park, Sang Kyu ^{[26
]}

机构：

[1] Yeungnam Univ, Coll Med, Dept Pediat, Daegu, South Korea

[2] Seoul Natl Univ, Coll Med, Dept Pediat, Seoul, South Korea

[3] Seoul Natl Univ, Canc Inst, Seoul, South Korea

[4] Chonnam Natl Univ, Med Sch, Hwasun Hosp, Dept Pediat, Gwangju, South Korea

[5] Catholic Univ Korea, Coll Med, Dept Pediat, 222 Banpo Daero, Seoul 06591, South Korea

[6] Catholic Univ Korea, Coll Med, Seoul St Marys Hosp, Dept Hematol, Seoul, South Korea

[7] Pusan Natl Univ, Sch Med, Dept Pediat, Yangsan, South Korea

[8] Univ Ulsan, Coll Med, Childrens Hosp, Div Pediat Hematol Oncol,Dept Pediat,Asan Med Ctr, Seoul, South Korea

[9] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pediat, Seoul, South Korea

[10] Jeonbuk Natl Univ, Jeonbuk Natl Univ Hosp, Med Sch, Dept Pediat, Jeonju, South Korea

[11] Jeonbuk Natl Univ, Jeonbuk Natl Univ Hosp, Med Sch, Res Inst Clin Med, Jeonju, South Korea

[12] Daegu Fatima Hosp, Dept Pediat, Daegu, South Korea

[13] Yeungnam Univ, Coll Med, Dept Internal Med, Daegu, South Korea

[14] Yonsei Univ, Coll Med, Div Pediat Hematol & Oncol, Dept Pediat, Seoul, South Korea

[15] Keimyung Univ, Dongsan Med Ctr, Sch Med, Dept Pediat, Daegu, South Korea

[16] Keimyung Univ, Sch Med, Dept Internal Med, Div Hematooncol, Daegu, South Korea

[17] Chungnam Natl Univ, Coll Med, Dept Pediat, Daejeon, South Korea

[18] Gachon Univ, Gil Med Ctr, Dept Pediat, Incheon, South Korea

[19] Dong A Univ, Coll Med, Dept Pediat, Busan, South Korea

[20] Dong A Univ Hosp, Dept Hematol, Busan, South Korea

[21] Seoul Natl Univ, Coll Med, Bundang Hosp, Dept Pediat, Seongnam, South Korea

[22] Ajou Univ, Sch Med, Dept Pediat, Suwon, South Korea

[23] Natl Canc Ctr, Res Inst & Hosp, Ctr Pediat Oncol, Goyang, South Korea

[24] Inha Univ Hosp, Dept Pediat, Incheon, South Korea

[25] Gyeongsang Natl Univ, Sch Med, Dept Pediat, Jinju, South Korea

[26] Univ Ulsan, Sch Med, Dept Pediat, Ulsan, South Korea

[27] Daegu Catholic Univ, Sch Med, Dept Pediat, Daegu, South Korea

[28] Chungbuk Natl Univ Hosp, Dept Pediat, Cheongju, South Korea

[29] Korea Canc Ctr Hosp, Dept Pediat, Seoul, South Korea

来源：

JOURNAL OF KOREAN MEDICAL SCIENCE | 2020年 / 35卷 / 46期

关键词：

Hodgkin Lymphoma; Children; Adolescent; Young Adult; Late Complication; STEM-CELL TRANSPLANTATION; DISEASE; CHEMOTHERAPY; THERAPY; CANCER;

D O I：

10.3346/jkms.2020.35.e393

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Hodgkin's lymphoma (HL) constitutes 10%-20% of all malignant lymphomas and has a high cure rate (5-year survival, around 90%). Recently, interest has increased concerning preventing secondary complications (secondary cancer, endocrine disorders) in long-term survivors. We aimed to study the epidemiologic features and therapeutic outcomes of HL in children, adolescents, and young adults in Korea. Methods: We performed a multicenter, retrospective study of 224 patients aged < 25 years diagnosed with HL at 22 participating institutes in Korea from January 2007 to August 2016. Results: A higher percentage of males was diagnosed at a younger age. Nodular sclerosis histopathological HL subtype was most common, followed by mixed cellularity subtype. Eighty-one (36.2%), 101 (45.1%), and 42 (18.8%) patients were classified into low, intermediate, and high-risk groups, respectively. Doxorubicin, bleomycin, vinblastine, dacarbazine was the most common protocol (n = 102, 45.5%). Event-free survival rate was 86.0% 2.4%, while five-year overall survival (OS) rate was 96.1% +/- 1.4%: 98.7% +/- 1.3%, 97.7% +/- 1.6%, and 86.5% +/- 5.6% in the low, intermediate, and high-risk groups, respectively (P = 0.021). Five-year OS was worse in patients with B-symptoms, stage IV disease, high risk, splenic involvement, extra-nodal lymphoma, and elevated lactate dehydrogenase level. In multivariate analysis, B-symptoms and extra-nodal involvement were prognostic factors for poor OS. Late complications of endocrine disorders and secondary malignancy were observed in 17 and 6 patients, respectively. Conclusion: This is the first study on the epidemiology and treatment outcomes of HL in children, adolescents, and young adults in Korea. Future prospective studies are indicated to develop therapies that minimize treatment toxicity while maximizing cure rates in children, adolescents, and young adults with HL.

引用

页数：16

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