Cerebral Amyloid Deposition and Dual-Tasking in Cognitively Normal, Mobility Unimpaired Older Adults

被引：13

作者：

Nadkami, Neelesh K. ^{[1
,2
]}

Lopez, Oscar L. ^{[2
,3
,4
]}

Perera, Subashan ^{[1
,5
]}

Studenski, Stephanie A. ^{[6
]}

Snitz, Beth E. ^{[2
,3
]}

Erickson, Kirk I. ^{[7
]}

Mathis, Chester A. ^{[8
]}

Nebes, Robert D. ^{[4
]}

Redfern, Mark ^{[9
]}

Klunk, William E. ^{[2
,3
,4
]}

机构：

[1] Univ Pittsburgh, Dept Med Geriatr Med, 500-3471 5th Ave, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Alzheimers Dis Res Ctr, 500-3471 5th Ave, Pittsburgh, PA 15213 USA

[3] Univ Pittsburgh, Dept Neurol, 500-3471 5th Ave, Pittsburgh, PA 15213 USA

[4] Univ Pittsburgh, Dept Psychiat, 500-3471 5th Ave, Pittsburgh, PA 15213 USA

[5] Univ Pittsburgh, Dept Biostat, 500-3471 5th Ave, Pittsburgh, PA 15213 USA

[6] NIA, Intramural Res Program, Baltimore, MD 21224 USA

[7] Univ Pittsburgh, Dept Psychol, 500-3471 5th Ave, Pittsburgh, PA 15213 USA

[8] Univ Pittsburgh, Dept Radiol, 500-3471 5th Ave, Pittsburgh, PA 15213 USA

[9] Univ Pittsburgh, Swanson Sch Engn, 500-3471 5th Ave, Pittsburgh, PA 15213 USA

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2017年 / 72卷 / 03期

关键词：

Cognition; Gait; Alzheimer's disease; FUNCTIONAL CONNECTIVITY; ALZHEIMERS-DISEASE; WORKING-MEMORY; GAIT VELOCITY; WALKING; RISK; BURDEN; HYPERINTENSITIES; INTERFERENCE; ASSOCIATION;

D O I：

10.1093/gerona/glw211

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background: We examined relationships between cerebral amyloid-beta (A beta) and cognitive-gait dual-task performance in 27 cognitively normal, mobility unimpaired elders. Methods: We assessed A beta on Pittsburgh Compound B (PiB)-PET. We measured gait speed separately and while performing working-memory, response-inhibition, motor-sequencing, and phone-dialing tasks. We compared dual-task costs on gait and cognitive performance in high-A beta (PiB(+)) and low-A beta (PiB(-)) groups and examined the association between A beta and dual-task performance decrements. Results: PiB(+) (n = 16) were comparable with the PiB(-) (n = 11) individuals on demographics, general cognitive and physical performance, and key brain MRI characteristics. PiB(+) group demonstrated greater dual-task costs on gait speed on all cognitive tasks (p <.05) except on response inhibition. Dual-task costs on cognition were similar between groups. Overall, A beta was associated with dual-task decrement on gait speed but not on dual-task decrement on cognitive performance. Conclusions: Preliminary evidence indicates that cerebral A beta is associated with gait slowing on dual-tasking in healthy older adults.

引用

页码：431 / 437

页数：7

共 33 条

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