Rhodium-Catalyzed Addition Cyclization of Hydrazines with Alkynes: Pyrazole Synthesis via Unexpected C-N Bond Cleavage

被引：63
|
作者：
Li, Deng Yuan
Mao, Xiao Feng
Chen, Hao Jie
Chen, Guo Rong
Liu, Pei Nian [1 ]
机构：
[1] E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China
来源：
ORGANIC LETTERS | 2014年 / 16卷 / 13期
关键词：
REGIOSELECTIVE SYNTHESIS; INTRAMOLECULAR CARBOALKOXYLATION; DECARBONYLATIVE ADDITION; GOLD; PLATINUM; NICKEL; CARBOSTANNYLATION; CYCLOADDITION; ARYNES; CARBOTHIOLATION;
D O I：
10.1021/ol501402p
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Rhodium-catalyzed addition-cyclization of hydrazines with alkynes has been achieved to afford highly substituted pyrazoles under mild conditions. The cascade reaction involves two transformations: addition of the C-N bond of hydrazines to alkynes via unexpected C-N bond cleavage and intramolecular dehydration cyclization.
引用
收藏
页码：3476 / 3479
页数：4
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