Mesenchymal Stem Cell-Derived Extracellular Vesicles for Therapeutic Use and in Bioengineering Applications

被引：26

作者：

McLaughlin, Caroline ^{[1
]}

Datta, Pallab ^{[2
]}

Singh, Yogendra P. ^{[3
]}

Lo, Alexis ^{[1
]}

Horchler, Summer ^{[1
]}

Elcheva, Irina A. ^{[4
]}

Ozbolat, Ibrahim T. ^{[3
,6
]}

Ravnic, Dino J. ^{[1
]}

Koduru, Srinivas, V ^{[1
,5
]}

机构：

[1] Penn State Hlth Milton S Hershey Med Ctr, Dept Surg, Hershey, PA 17033 USA

[2] Natl Inst Pharmaceut Educ & Res NIPER Kolkata, Dept Pharmaceut, Kolkata 700054, W Bengal, India

[3] Penn State Univ, Mat Res Inst, Huck Inst Life Sci, Dept Biomed Engn, University Pk, PA 16802 USA

[4] Penn State Coll Med, Dept Pediat, Hematol Oncol, Hershey, PA 17033 USA

[5] Penn State Coll Med, Dept Cellular & Mol Physiol, Hershey, PA 17033 USA

[6] Cukurova Univ, Dept Med Oncol, TR-01330 Adana, Turkey

来源：

CELLS | 2022年 / 11卷 / 21期

关键词：

stem cells; EVs; extracellular vesicles; bioprinting; biomarkers; MSCs; ACUTE KIDNEY INJURY; CARTILAGE REGENERATION; PROMOTE ANGIOGENESIS; HORIZONTAL TRANSFER; MESSENGER-RNA; STROMAL CELLS; RENAL INJURY; T-CELLS; EXOSOMES; MICROVESICLES;

D O I：

10.3390/cells11213366

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Extracellular vesicles (EVs) are small lipid bilayer-delimited particles that are naturally released from cells into body fluids, and therefore can travel and convey regulatory functions in the distal parts of the body. EVs can transmit paracrine signaling by carrying over cytokines, chemokines, growth factors, interleukins (ILs), transcription factors, and nucleic acids such as DNA, mRNAs, microRNAs, piRNAs, lncRNAs, sn/snoRNAs, mtRNAs and circRNAs; these EVs travel to predecided destinations to perform their functions. While mesenchymal stem cells (MSCs) have been shown to improve healing and facilitate treatments of various diseases, the allogenic use of these cells is often accompanied by serious adverse effects after transplantation. MSC-produced EVs are less immunogenic and can serve as an alternative to cellular therapies by transmitting signaling or delivering biomaterials to diseased areas of the body. This review article is focused on understanding the properties of EVs derived from different types of MSCs and MSC-EV-based therapeutic options. The potential of modern technologies such as 3D bioprinting to advance EV-based therapies is also discussed.

引用

页数：27

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