Expressions of ABCG2, CD133, and Podoplanin in Salivary Adenoid Cystic Carcinoma

被引:10
作者
Li, Wuwei [1 ]
Tamamura, Ryo [2 ]
Wang, Bo [3 ]
Liu, Qigui [4 ]
Liu, Han [1 ]
Liu, Tingjiao [1 ]
Katase, Naoki [5 ]
Xiao, Jing [1 ]
Nagatsuka, Hitoshi [5 ]
机构
[1] Dalian Med Univ, Med Coll Stomatol, Dalian 116044, Peoples R China
[2] Nihon Univ, Sch Dent Matsudo, Dept Histol, Matsudo, Chiba 2718587, Japan
[3] Northwestern Univ, Feinberg Sch Med, Dept Surg, Comprehens Transplant Ctr, Chicago, IL 60611 USA
[4] Dalian Med Univ, Dept Hlth Stat, Dalian 116044, Peoples R China
[5] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Oral Pathol & Med, Okayama 7008525, Japan
关键词
CANCER STEM-CELL; RESISTANCE PROTEIN TRANSPORTER; SIDE-POPULATION; PROSPECTIVE IDENTIFICATION; PROXIMAL TUBULE; MARKER; CAPACITY; ANTIGEN; GROWTH; TUMORS;
D O I
10.1155/2014/132349
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Adenoid cystic carcinoma (ACC) is one of the most common salivary gland malignant tumors with a high risk of recurrence and metastasis. Current studies on cancer stem cells (CSCs) have verified that CSCs are the driving force behind tumor initiation and progression, suggesting that new cancer therapies may be established by effectively targeting and killing the CSCs. The primary goal of this study is to investigate the expression patterns of ABCG2, CD133, and podoplanin in ACC of minor salivary glands by immunohistochemistry analysis. We found that ABCG2 was weakly expressed in normal looking salivary gland tissues. A significant upregulation of ABCG2 expression in ACC was observed with a similar expression pattern of Ki-67. CD133 was detected in apical membrane of epithelial cells and podoplanin was expressed positively in myoepithelial cells of both normal looking tissue and ACC. However, no significant difference was found of the expression pattern of CD133 and podoplanin between normal looking tissues and ACC. Our observations suggest that CSCs may exist in quiescent cells with ABCG2 positive staining, which are surrounded by cells with positive expression of ABCG2 and Ki-67 in ACC, and costaining with ABCG2 and Ki-67 may help predict the location of CSCs.
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页数:11
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