Characterization of the classical biological false-positive reaction in the serological test for syphilis in the modern era

被引:39
作者
Liu, Fan [1 ,3 ]
Liu, Li-Li [1 ,5 ,6 ]
Guo, Xiao-Jing [1 ]
Xi, Ya [1 ]
Lin, Li-Rong [1 ,6 ]
Zhang, Hui-Lin [1 ]
Huang, Song-Jie [1 ]
Chen, Yu-Yan [1 ]
Zhang, Ya-Feng [1 ]
Zhang, Qiao [1 ]
Huang, Ge-Ling [7 ]
Tong, Man-Li [1 ]
Jiang, Jie [1 ,2 ]
Yang, Tian-Ci [1 ,4 ,6 ]
机构
[1] Xiamen Univ, Zhongshan Hosp, Coll Med, Xiamen 361004, Peoples R China
[2] Xiamen Univ, Affiliated Hosp 1, Coll Med, Xiamen 361003, Peoples R China
[3] Xiamen Univ, Coll Med, Xiamen 361004, Peoples R China
[4] Xiamen Univ, ShenZhen Res Inst, Shenzhen 518057, Peoples R China
[5] Fujian Med Univ, Xiamen Zhongshan Hosp, Xiamen 361004, Peoples R China
[6] Fujian Univ Tradit Chinese Med, Xiamen Zhongshan Hosp, Xiamen 361004, Peoples R China
[7] Maternal & Child Hlth Hosp Xiamen, Xiamen 361000, Peoples R China
基金
中国国家自然科学基金;
关键词
Syphilis; Biological false positive; Nontreponemal antibody test; Rapid plasma reagin; Treponema pallidum particle agglutination; TREPONEMA-PALLIDUM; LABORATORY DIAGNOSIS; DISEASE; IMMUNOASSAY; MANAGEMENT; ANTIGEN; ASSAY;
D O I
10.1016/j.intimp.2014.03.011
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
To characterize the CBFP reaction in the modem era, we analyzed the results of parallel rapid plasma reagin (RPR) and Treponema pallidum particle agglutination (TPPA) tests from a total of 63,765 blood samples obtained at Zhongshan Hospital in the Medical College of Xiamen University from May 2008 to February 2013. Among the 63,765 tested blood samples, 206 (0.32%) had the CBFP reaction. In multivariate analysis, an increased likelihood of the CBFP reaction was associated with female subjects, subjects >= 2.80 years old, and subjects between 16 and 35 years old (P < 0.05). The CBFP reaction occurred in association with 17 categories of disease, including 60 types of diseases, in the 206 subjects. To our knowledge, a number of these diseases had not been previously reported to be associated with the CBFP in the RPR test, including false labor, megaloblastic anemias, aplastic anemias, redundant prepuce, congenital malformation of heart, and salpingitis. Among the 206 patients with the CBFP reaction, 35 patients were subjected to follow-up for five years. 26 out of 35 these patients were at a 1:1 initial RPR titer, 8 out of 35 patients were at a 1:2 initial RPR titer, and 1 out of 35 patients were at a 1:4 initial RPR titer. 30 subjects had their RPR seroreverted. In our opinion, additional CBFP research using a large sample population will contribute to the identification of additional underlying serious disorders that are not related to syphilis. Such results could be useful for the prediction and diagnosis of these diseases. (c) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码:331 / 336
页数:6
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