Review of the Uses of Vagal Nerve Stimulation in Chronic Pain Management

被引：105
作者：
Chakravarthy, Krishnan [1 ]
Chaudhry, Hira [1 ]
Williams, Kayode [1 ]
Christo, Paul J. [1 ]
机构：
[1] Johns Hopkins Sch Med, Div Pain Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21287 USA
来源：
CURRENT PAIN AND HEADACHE REPORTS | 2015年 / 19卷 / 12期
关键词：
Vagal nerve stimulation; Chronic pain; Headache; Inflammation; Pelvic pain; Fibromyalgia; TREATMENT-RESISTANT DEPRESSION; VAGUS-NERVE; ELECTRICAL-STIMULATION; REFRACTORY EPILEPSY; VENTRICULAR ASYSTOLE; AFFERENT STIMULATION; NOCICEPTIVE REFLEX; ALZHEIMERS-DISEASE; SPINAL NEURONS; CENTRAL RELAYS;
D O I：
10.1007/s11916-015-0528-6
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Recent human and animal studies provide growing evidence that vagal nerve stimulation (VNS) can deliver strong analgesic effects in addition to providing therapeutic efficacy in the treatment of refractory epilepsy and depression. Analgesia is potentially mediated by vagal afferents that inhibit spinal nociceptive reflexes and transmission and have strong anti-inflammatory properties. The purpose of this review is to provide pain practitioners with an overview of VNS technology and limitations. It specifically focuses on clinical indications of VNS for various chronic pain syndromes, including fibromyalgia, pelvic pain, and headaches. We also present potential mechanisms for VNS modulation of chronic pain by reviewing both animal and human studies.
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页数：9
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