Small-molecule fluorescent probes for specific detection and imaging of chemical species inside lysosomes

被引：115

作者：

Zhu, Jun-Long ^{[1
]}

Xu, Zheng ^{[2
]}

Yang, Yangyang ^{[3
]}

Xu, Lin ^{[1
,4
]}

机构：

[1] East China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Sch Chem & Mol Engn, 3663 N Zhongshan Rd, Shanghai, Peoples R China

[2] Monash Univ, Monash Inst Pharmaceut Sci, Med Chem, Clayton, Vic, Australia

[3] East China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai, Peoples R China

[4] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 47期

基金：

中国国家自然科学基金;

关键词：

HIGHLY SELECTIVE DETECTION; LARGE STOKES SHIFT; HYDROGEN-SULFIDE; HYPOCHLOROUS ACID; REACTIVE OXYGEN; LIPID-PEROXIDATION; AQUEOUS-SOLUTION; LIVE CELLS; LIVING CELLS; BETA-GALACTOSIDASE;

D O I：

10.1039/c9cc03299a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the past few years, the preparation of novel small-molecule fluorescent probes for specific detection and imaging of chemical species inside lysosomes has attracted considerable attention because of their wide applications in chemistry, biology, and medical science. This feature article summarizes the recent advances in the design and preparation of small-molecule fluorescent probes for specific detection of chemical species inside lysosomes. In addition, their properties and applications for the detection and imaging of pH, H2O2, HOCl, O-2(center dot), lipid peroxidation, H2S, HSO3, thiols, NO, ONOO, HNO, Zn2+, Cu2+, enzymes, etc. in lysosomes are discussed as well.

引用

页码：6629 / 6671

页数：43

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