Cardiac chimerism in recipients of peripheral-blood and bone marrow stem cells

被引：15
作者：
Bayes-Genis, A
Muñiz-Diaz, E
Catasus, L
Arilla, M
Rodriguez, C
Sierra, J
Madoz, PJ
Cinca, J
机构：
[1] Hosp Santa Creu & Sant Pau, Serv Cardiol, Barcelona 08025, Spain
[2] Hosp Santa Creu & Sant Pau, Blood Bank, Barcelona 08025, Spain
[3] Hosp Santa Creu & Sant Pau, Pathol Serv, Barcelona 08025, Spain
[4] Hosp Santa Creu & Sant Pau, Serv Hematol, Barcelona 08025, Spain
来源：
EUROPEAN JOURNAL OF HEART FAILURE | 2004年 / 6卷 / 04期
关键词：
D O I：
10.1016/j.ejheart.2003.12.006
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Multipotent progenitor cells have the ability to differentiate into most somatic cell types, including cardiac myocytes. We sought to investigate cardiac chimerism after peripheral-blood and bone marrow stem cell transplantation. Between 10 and 17 highly polymorphic short tandem repeat (STR) markers were assayed in DNA obtained from donors' peripheral blood, recipients' peripheral blood before transplantation, and the recipient's heart in every patient. Gender and non-gender STR donor alleles were identified in the recipient heart in three patients. Using a highly sensitive PCR assay to determine donor and recipient genotypes, we confirmed the existence of cardiac chimerism in recipients of peripheral-blood and bone marrow stem cells. (C) 2004 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：399 / 402
页数：4
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