Endo-and exocytic budding transformation of slow-diffusing membrane domains induced by Alzheimer's amyloid beta

被引：13

作者：

Morita, Masamune ^{[1
]}

Hamada, Tsutomu ^{[1
]}

Vestergaard, Mun'delanji C. ^{[1
]}

Takagi, Masahiro ^{[1
]}

机构：

[1] Japan Adv Inst Sci & Technol, Sch Mat Sci, Nomi City, Ishikawa 9231292, Japan

来源：

PHYSICAL CHEMISTRY CHEMICAL PHYSICS | 2014年 / 16卷 / 19期

关键词：

CELL-SIZED LIPOSOMES; INTRAMEMBRANE DOMAINS; LIPID-MEMBRANES; DYNAMICS; VESICLES; OLIGOMERS; LOCALIZATION; A-BETA(1-42); SEPARATION; MIXTURES;

D O I：

10.1039/c4cp00434e

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Cell-sized liposomes are a powerful tool for clarifying physicochemical mechanisms that govern molecular interactions. Herein, budding transformation of membrane domains was induced by amyloid beta peptides. The peptides increased the membrane viscosity as demonstrated by the Brownian motion of membrane domains. These results could aid in understanding the physicochemical mechanism of Alzheimer's disease.

引用

页码：8773 / 8777

页数：5

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