Osteogenic activity and antibacterial effect of zinc ion implanted titanium

被引：229

作者：

Jin, Guodong ^{[1
]}

Cao, Huiliang ^{[1
]}

Qiao, Yuqin ^{[1
]}

Meng, Fanhao ^{[1
]}

Zhu, Hongqin ^{[1
]}

Liu, Xuanyong ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2014年 / 117卷

基金：

中国国家自然科学基金;

关键词：

Zinc; Titanium; Plasma immersion ion implantation; Osteogenic activity; Antibacterial effect; ALKALINE-PHOSPHATASE ACTIVITY; SURFACE MODIFICATION; CELL-PROLIFERATION; BONE-FORMATION; STROMAL CELLS; METAL-IONS; ZN; DIFFERENTIATION; PLAQUE; ACID;

D O I：

10.1016/j.colsurfb.2014.02.025

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Titanium (Ti) and its alloys are widely used as orthopedic and dental implants. In this work, zinc (Zn) was implanted into oxalic acid etched titanium using plasma immersion ion implantation technology. Scanning electron microscopy and X-ray photoelectron spectroscopy were used to investigate the surface morphology and composition of Zn-implanted titanium. The results indicate that the depth profile of zinc in Zn-implanted titanium resembles a Gaussian distribution, and zinc exists in the form of ZnO at the surface whereas in the form of metallic Zn in the interior. The Zn-implanted titanium can significantly stimulate proliferation of osteoblastic MC3T3-E1 cells as well as initial adhesion, spreading activity, ALP activity, collagen secretion and extracellular matrix mineralization of the rat mesenchymal stem cells. The Zn-implanted titanium presents partly antibacterial effect on both Escherichia coli and Staphylococcus aureus. The ability of the Zn-implanted titanium to stimulate cell adhesion, proliferation and differentiation as well as the antibacterial effect on E. coli can be improved by increasing implantation time even to 2 h in this work, indicating that the content of zinc implanted in titanium can easily be controlled within the safe concentration using plasma immersion ion implantation technology. The Zn-implanted titanium with excellent osteogenic activity and partly antibacterial effect can serve as useful candidates for orthopedic and dental implants. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：158 / 165

页数：8

共 47 条

[1] Enhanced Antibacterial Activity of Nanocrystalline ZnO Due to Increased ROS-Mediated Cell Injury [J].