Telomerase-specific oncolytic adenovirus expressing TRAIL suppresses peritoneal dissemination of gastric cancer

被引：29

作者：

Zhou, W. ^{[1
,2
]}

Dai, S. ^{[1
,2
]}

Zhu, H. ^{[1
,2
]}

Song, Z. ^{[1
,2
]}

Cai, Y. ^{[3
]}

Lee, J. B. ^{[3
]}

Li, Z. ^{[3
]}

Hu, X. ^{[2
]}

Fang, B. ^{[4
]}

He, C. ^{[1
,2
]}

Huang, X. ^{[1
]}

机构：

[1] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Colorectal Surg, 3 Qingchun East Rd, Hangzhou 310016, Zhejiang, Peoples R China

[2] Key Lab Biotherapy Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China

[3] George Washington Univ, Med Sch, Dept Biochem & Mol Med, Washington, DC USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Thorac & Cardiovasc Surg, Houston, TX 77030 USA

来源：

GENE THERAPY | 2017年 / 24卷 / 04期

基金：

中国国家自然科学基金;

关键词：

GENE-THERAPY; INTRAPERITONEAL CHEMOTHERAPY; CYTOREDUCTIVE SURGERY; TUMOR-GROWTH; CELLS; REPLICATION; PROMOTER; STRATEGIES; APOPTOSIS; LIGAND;

D O I：

10.1038/gt.2017.2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peritoneal dissemination is the most common condition of metastasis in gastric cancer. The survival duration of a patient with advanced stage gastric cancer, may be improved by gene therapy. In this study, we used an oncolytic adenovirus vector (Ad/TRAILE1) that expresses both the TRAIL and E1A genes under the control of a tumor-specific promoter. We evaluated the anti-tumor effect of Ad/TRAIL-E1 on gastric cancer cells in vitro, as well as in vivo in a xenograft peritoneal carcinomatosis mouse model. Our data showed that Ad/TRAIL-E1 induced TRAIL-mediated apoptosis in gastric cancer cell lines, but not in the normal cell lines. In addition, Ad/TRAIL-E1 significantly inhibited peritoneal metastasis and prolonged the survival of mice without treatment-related toxicity. Therefore, tumor-specific TRAIL expression from an oncolytic adenovirus vector may provide a novel therapeutic approach for the treatment of advance stage gastric cancer with peritoneal dissemination.

引用

页码：199 / 207

页数：9

共 35 条

[1] Strategies to decrease the incidence of intra-abdominal recurrence in resectable gastric cancer [J].

Averbach, AM ;

Jacquet, P .

BRITISH JOURNAL OF SURGERY, 1996, 83 (06) :726-733

[2] Oncolysis and suppression of tumor growth by a GFP-expressing oncolytic adenovirus controlled by an hTERT and CMV hybrid promoter [J].

Davis, J. J. ;

Wang, L. ;

Dong, F. ;

Zhang, L. ;

Guo, W. ;

Teraishi, F. ;

Xu, K. ;

Ji, L. ;

Fang, B. .

CANCER GENE THERAPY, 2006, 13 (07) :720-723

[3] Eliminating established tumor in nu/nu nude mice by a tumor necrosis factor-α-related apoptosis-inducing ligand-armed oncolytic adenovirus [J].

Dong, Fengqin ;

Wang, Li ;

Davis, John J. ;

Hu, Wenxian ;

Zhang, Lidong ;

Guo, Wei ;

Teraishi, Fuminori ;

Ji, Lin ;

Fang, Bingliang .

CLINICAL CANCER RESEARCH, 2006, 12 (17) :5224-5230

[4] Evaluation of GAL4/TATA in vivo -: Induction of transgene expression by adenovirally mediated gene codelivery [J].

Fang, BL ;

Ji, L ;

Bouvet, M ;

Roth, JA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (09) :4972-4975

[5] Toward Curative Treatment of Peritoneal Carcinomatosis From Nonovarian Origin by Cytoreductive Surgery Combined With Perioperative Intraperitoneal Chemotherapy A Multi-Institutional Study of 1290 Patients [J].

Glehen, Olivier ;

Gilly, Francois N. ;

Boutitie, Florent ;

Bereder, Jean M. ;

Quenet, Francois ;

Sideris, Lucas ;

Mansvelt, Baudouin ;

Lorimier, Gerard ;

Msika, Simon ;

Elias, Dominique .

CANCER, 2010, 116 (24) :5608-5618

[6] Treatment strategies for gastric cancer patients with peritoneal metastasis [J].

Imano, Motohiro ;

Okuno, Kiyotaka .

SURGERY TODAY, 2014, 44 (03) :399-404

[7] Trastuzumab-Based Photoimmunotherapy Integrated with Viral HER2 Transduction Inhibits Peritoneally Disseminated HER2-Negative Cancer [J].

Ishida, Michihiro ;

Kagawa, Shunsuke ;

Shimoyama, Kyoko ;

Takehara, Kiyoto ;

Noma, Kazuhiro ;

Tanabe, Shunsuke ;

Shirakawa, Yasuhiro ;

Tazawa, Hiroshi ;

Kobayashi, Hisataka ;

Fujiwara, Toshiyoshi .

MOLECULAR CANCER THERAPEUTICS, 2016, 15 (03) :402-411

[8] Suppressing orthotopic pancreatic tumor growth with a fiber-modified adenovector expressing the TRAIL gene from the human telomerase reverse transcriptase promoter [J].

Jacob, D ;

Davis, J ;

Zhu, HB ;

Zhang, LD ;

Teraishi, F ;

Wu, SH ;

Marini, FC ;

Fang, BL .

CLINICAL CANCER RESEARCH, 2004, 10 (10) :3535-3541

[9]

Jemal A, 2009, CA-CANCER J CLIN, V59, P225, DOI [10.3322/caac.20006, 10.3322/caac.21254, 10.3322/caac.21332, 10.3322/caac.21551, 10.3322/caac.20073, 10.3322/caac.21387, 10.3322/caac.21654, 10.3322/caac.21601]

[10] The TRAIL apoptotic pathway in cancer onset, progression and therapy [J].

Johnstone, Ricky W. ;

Frew, Ailsa J. ;

Smyth, Mark J. .

NATURE REVIEWS CANCER, 2008, 8 (10) :782-798

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