Managing Hypertension in Patients with CKD: A Marathon, Not a SPRINT

被引：18

作者：

Chertow, Glenn M. ^{[1
]}

Beddhu, Srinivasan ^{[2
]}

Lewis, Julia B. ^{[3
]}

Toto, Robert D. ^{[4
]}

Cheung, Alfred K. ^{[2
]}

机构：

[1] Stanford Univ, Dept Med, Div Nephrol, Stanford, CA 94305 USA

[2] Univ Utah, Internal Med Sch Med, Div Nephrol, Salt Lake City, UT USA

[3] Vanderbilt Univ, Dept Med, Div Nephrol & Hypertens, Nashville, TN USA

[4] SW Texas State Univ, Dept Clin Sci, Dallas, TX USA

来源：

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2016年 / 27卷 / 01期

基金：

美国国家卫生研究院;

关键词：

BLOOD-PRESSURE CONTROL; ESTROGEN PLUS PROGESTIN; TRIAL; AGE;

D O I：

10.1681/ASN.2015101125

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

In this manuscript, nephrologist-investigators from one of five Clinical Center Networks of the Systolic Blood Pressure Intervention Trial (SPRINT) provide background information and context on the intensity of anti-hypertensive therapy in conjunction with the release of detailed results from SPRINT's primary analysis. The authors highlight published evidence on the safety and efficacy of differing intensities of anti-hypertensive therapy in mild to moderate CKD, where SPRINT will help to inform practice, as well as where gaps in evidence will remain. The authors also challenge the nephrology community to renew its attention and efforts on hypertension clinical care and research.

引用

页码：40 / 43

页数：4

共 12 条

[1] The design and rationale of a multicenter clinical trial comparing two strategies for control of systolic blood pressure: The Systolic Blood Pressure Intervention Trial (SPRINT) [J].

Ambrosius, Walter T. ;

Sink, Kaycee M. ;

Foy, Capri G. ;

Berlowitz, Dan R. ;

Cheung, Alfred K. ;

Cushman, William C. ;

Fine, Lawrence J. ;

Goff, David C., Jr. ;

Johnson, Karen C. ;

Killeen, Anthony A. ;

Lewis, Cora E. ;

Oparil, Suzanne ;

Reboussin, David M. ;

Rocco, Michael V. ;

Snyder, Joni K. ;

Williamson, Jeff D. ;

Wright, Jackson T., Jr. ;

Whelton, Paul K. .

CLINICAL TRIALS, 2014, 11 (05) :532-546

[2]

[Anonymous], 1989, NEW ENGL J MED, V321, P406

[3] Intensive Blood-Pressure Control in Hypertensive Chronic Kidney Disease [J].

Appel, Lawrence J. ;

Wright, Jackson T., Jr. ;

Greene, Tom ;

Agodoa, Lawrence Y. ;

Astor, Brad C. ;

Bakris, George L. ;

Cleveland, William H. ;

Charleston, Jeanne ;

Contreras, Gabriel ;

Faulkner, Marquetta L. ;

Gabbai, Francis B. ;

Gassman, Jennifer J. ;

Hebert, Lee A. ;

Jamerson, Kenneth A. ;

Kopple, Joel D. ;

Kusek, John W. ;

Lash, James P. ;

Lea, Janice P. ;

Lewis, Julia B. ;

Lipkowitz, Michael S. ;

Massry, Shaul G. ;

Miller, Edgar R. ;

Norris, Keith ;

Phillips, Robert A. ;

Pogue, Velvie A. ;

Randall, Otelio S. ;

Rostand, Stephen G. ;

Smogorzewski, Miroslaw J. ;

Toto, Robert D. ;

Wang, Xuelei .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (10) :918-929

[4] Treatment of hypertension in patients 80 years of age or older [J].

Beckett, Nigel S. ;

Peters, Ruth ;

Fletcher, Astrid E. ;

Staessen, Jan A. ;

Liu, Lisheng ;

Dumitrascu, Dan ;

Stoyanovsky, Vassil ;

Antikainen, Riitta L. ;

Nikitin, Yuri ;

Anderson, Craig ;

Belhani, Alli ;

Forette, Francoise ;

Rajkumar, Chakravarthi ;

Thijs, Lutgarde ;

Banya, Winston ;

Bulpitt, Christopher J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (18) :1887-1898

[5] Impact of achieved blood pressure on cardiovascular outcomes in the irbesartan diabetic nephropathy trial [J].

Berl, T ;

Hunsicker, LG ;

Lewis, JB ;

Pfeffer, MA ;

Porush, JG ;

Rouleau, JL ;

Drury, PL ;

Esmatjes, E ;

Hricik, D ;

Pohl, M ;

Raz, I ;

Vanhille, P ;

Wiegmann, TB ;

Wolfe, BM ;

Locatelli, F ;

Goldhaber, SZ ;

Lewis, EJ .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2005, 16 (07) :2170-2179

[6] Effects of Intensive Blood-Pressure Control in Type 2 Diabetes Mellitus [J].

Cushman, William C. ;

Evans, Gregory W. ;

Byington, Robert P. ;

Goff, David C., Jr. ;

Grimm, Richard H., Jr. ;

Cutler, Jeffrey A. ;

Simons-Morton, Denise G. ;

Basile, Jan N. ;

Corson, Marshall A. ;

Probstfield, Jeffrey L. ;

Katz, Lois ;

Peterson, Kevin A. ;

Friedewald, William T. ;

Buse, John B. ;

Bigger, J. Thomas ;

Gerstein, Hertzel C. ;

Ismail-Beigi, Faramarz .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 362 (17) :1575-1585

[7]

Gerstein HC, 2011, NEW ENGL J MED, V364, P818, DOI 10.1056/NEJMoa1006524

[8] Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women [J].

Hulley, S ;

Grady, D ;

Bush, T ;

Furberg, C ;

Herrington, D ;

Riggs, B ;

Vittinghoff, E .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 280 (07) :605-613

[9] THE EFFECTS OF DIETARY-PROTEIN RESTRICTION AND BLOOD-PRESSURE CONTROL ON THE PROGRESSION OF CHRONIC RENAL-DISEASE [J].

KLAHR, S ;

LEVEY, AS ;

BECK, GJ ;

CAGGIULA, AW ;

HUNSICKER, L ;

KUSEK, JW ;

STRIKER, G ;

BUCKALEW, V ;

BURKART, J ;

FURBERG, C ;

FELTS, J ;

MOORE, M ;

ROCCO, H ;

DOLECEK, T ;

WARREN, S ;

BEARDEN, B ;

STARKEY, C ;

HARVEY, J ;

POOLE, D ;

DAHLQUIST, S ;

DOROSHENKO, L ;

BRADHAM, K ;

WEST, D ;

AGOSTINO, J ;

COLE, L ;

BAKER, B ;

HAIRSTON, K ;

BURGOYNE, S ;

LAZARUS, J ;

STEINMAN, T ;

SEIFTER, J ;

DESMOND, M ;

FIORENZO, M ;

CHIAVACCI, A ;

METALIDES, T ;

KORZECRAMIREZ, D ;

GOULD, S ;

PICKETT, V ;

PORUSH, J ;

FAUBERT, P ;

SPITALEWITZ, S ;

FAUBERT, J ;

ZIMMER, G ;

SAUM, D ;

BLOCK, M ;

WOEL, J ;

ROSE, M ;

DENNIS, V ;

SCHWAB, S ;

MINDA, S .

NEW ENGLAND JOURNAL OF MEDICINE, 1994, 330 (13) :877-884

[10] Observational Modeling of Strict vs Conventional Blood Pressure Control in Patients With Chronic Kidney Disease [J].

Kovesdy, Csaba P. ;

Lu, Jun L. ;

Molnar, Miklos Z. ;

Ma, Jennie Z. ;

Canada, Robert B. ;

Streja, Elani ;

Kalantar-Zadeh, Kamyar ;

Bleyer, Anthony J. .

JAMA INTERNAL MEDICINE, 2014, 174 (09) :1442-1449

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