Primary reconstruction of pelvic floor defects following sacrectomy using Permacol™ graft

Aims: The large pelvic floor defect following sacrectonny for sacral masses leaves the challenging problem of primary closure and herniation. We present the outcome of primary repair using Permacol (TM), a biomaterial made of acellular porcine cross-linked dermal collagen and with similar tensile strength to polypropylene mesh. It is non-allergenic and possibly less likely (hall synthetic Mesh to Cause inflammation leading to small bowel adherence: fistula formation and graft extrusion. Following implantation. Permacol is colonized by host cells and resists degradation by host enzymes. Methods: Three patients had sacrectomy with primary repair of pelvic floor defects between March 2004 and August 2005. Two had excision of sacral chordomas and one excision of a sacrococcygeal teratoma. Repair of the defect was carried out using the Permacol graft, suturing to the sacrum. anococcygeal raphe and ischial spines. Two suction drains were placed superficial to the mesh. Results: All patients had gross en-bloc tumour resections and over a median follow-up period of I year (range 8-25 months), there were no complications related to primary repair. Conclusion: Primary closure of a large defect following sacrectomy using a Permacol graft, in our early experience seems to be convenient and safe without the development of herniation. (C) 2008 Elsevier Ltd. All rights reserved.