On-Chip Fragment-Based Approach for Discovery of High-Affinity Bivalent Inhibitors

[1] [Anonymous], 2001, ANGEW CHEM, V113, P1824

[2] Bartoli S., 2006, DRUG DISCOV TODAY TE, V3, P425, DOI DOI 10.1016/J.DDTEC.2006.12.001

[3] A robust small-molecule microarray platform for screening cell lysates [J]. CHEMISTRY & BIOLOGY, 2006, 13 (05): : 493 - 504

[4] Surface plasmon resonance imaging measurements of ultrathin organic films [J]. ANNUAL REVIEW OF PHYSICAL CHEMISTRY, 2000, 51 : 41 - 63

[5] A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design [J]. NATURE BIOTECHNOLOGY, 2005, 23 (02) : 201 - 207

[6] A fragment-based approach for the discovery of isoform-specific p38α inhibitors [J]. ACS CHEMICAL BIOLOGY, 2007, 2 (05) : 329 - 336

[7] Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (40) : 9648 - 9654

[8] A rule of three for fragment-based lead discovery? [J]. DRUG DISCOVERY TODAY, 2003, 8 (19) : 876 - 877

[9] Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of β-secretase [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2007, 50 (06) : 1124 - 1132

[10] Custom chemical microarray production and affinity fingerprinting for the S1 pocket of factor VIIa [J]. ANALYTICAL BIOCHEMISTRY, 2004, 335 (01) : 50 - 57

[1] [Anonymous], 2001, ANGEW CHEM, V113, P1824

[2] Bartoli S., 2006, DRUG DISCOV TODAY TE, V3, P425, DOI DOI 10.1016/J.DDTEC.2006.12.001

[3] A robust small-molecule microarray platform for screening cell lysates [J]. CHEMISTRY & BIOLOGY, 2006, 13 (05): : 493 - 504

[4] Surface plasmon resonance imaging measurements of ultrathin organic films [J]. ANNUAL REVIEW OF PHYSICAL CHEMISTRY, 2000, 51 : 41 - 63

[5] A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design [J]. NATURE BIOTECHNOLOGY, 2005, 23 (02) : 201 - 207

[6] A fragment-based approach for the discovery of isoform-specific p38α inhibitors [J]. ACS CHEMICAL BIOLOGY, 2007, 2 (05) : 329 - 336

[7] Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (40) : 9648 - 9654

[8] A rule of three for fragment-based lead discovery? [J]. DRUG DISCOVERY TODAY, 2003, 8 (19) : 876 - 877

[9] Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of β-secretase [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2007, 50 (06) : 1124 - 1132

[10] Custom chemical microarray production and affinity fingerprinting for the S1 pocket of factor VIIa [J]. ANALYTICAL BIOCHEMISTRY, 2004, 335 (01) : 50 - 57