Microsatellites: Simple sequences with complex evolution

被引：1616
作者：
Ellegren, H [1 ]
机构：
[1] Uppsala Univ, Dept Evolut Biol, Evolut Biol Ctr, SE-75236 Uppsala, Sweden
来源：
NATURE REVIEWS GENETICS | 2004年 / 5卷 / 06期
关键词：
D O I：
10.1038/nrg1348
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Few genetic markers, if any, have found such widespread use as microsatellites, or simple/short tandem repeats. Features such as hypervariability and ubiquitous occurrence explain their usefulness, but these features also pose several questions. For example, why are microsatellites so abundant, why are they so polymorphic and by what mechanism do they mutate? Most importantly, what governs the intricate balance between the frequent genesis and expansion of simple repetitive arrays, and the fact that microsatellite repeats rarely reach appreciable lengths? In other words, how do microsatellites evolve?
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页码：435 / 445
页数：11
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