BioMEMS for medicine: On-chip cell characterization and implantable microelectrodes

被引:23
作者
Cheung, Karen C.
Renaud, Philippe
机构
[1] Univ British Columbia, Dept Elect & Comp Engn, Vancouver, BC V6T 1Z4, Canada
[2] Ecole Polytech Fed Lausanne, Lausanne, Switzerland
关键词
bioMEMS; dielectric characterization; implantable devices;
D O I
10.1016/j.sse.2006.03.023
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
This paper surveys a few of the emerging bioMEMS technologies at EPFL for improved, inexpensive health care. The lab-on-a-chip systems use dielectrophoretic forces to direct cell movement within microfluidic networks and impedance spectroscopy for label-free inflow characterization of living cells. The implantable microelectrodes for neural applications are based on thin-film polymer foils with embedded microelectrodes for both recording and stimulation. Applications for these biomedical microdevices will include stem cell research, cancer cell characterization, drug discovery, treatments for neurological disorders, and neuroprosthetic devices. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:551 / 557
页数:7
相关论文
共 31 条
[1]   Characterization of heterogeneous systems by dielectric spectroscopy [J].
Asami, K .
PROGRESS IN POLYMER SCIENCE, 2002, 27 (08) :1617-1659
[2]   A SILICON-BASED, 3-DIMENSIONAL NEURAL INTERFACE - MANUFACTURING PROCESSES FOR AN INTRACORTICAL ELECTRODE ARRAY [J].
CAMPBELL, PK ;
JONES, KE ;
HUBER, RJ ;
HORCH, KW ;
NORMANN, RA .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1991, 38 (08) :758-768
[3]   Impedance spectroscopy flow cytometry: On-chip label-free cell differentiation [J].
Cheung, K ;
Gawad, S ;
Renaud, P .
CYTOMETRY PART A, 2005, 65A (02) :124-132
[4]  
CHEUNG KC, 2004, 17 IEEE INT C MEMS M
[5]  
CHEUNG KC, 2004, 8 INT C MICR TOT AN
[6]   A cultural renaissance: in vitro cell biology embraces three-dimensional context [J].
Edelman, DB ;
Keefer, EW .
EXPERIMENTAL NEUROLOGY, 2005, 192 (01) :1-6
[7]   Time domain dielectric spectroscopy study of biological systems [J].
Feldman, Y ;
Ermolina, I ;
Hayashi, Y .
IEEE TRANSACTIONS ON DIELECTRICS AND ELECTRICAL INSULATION, 2003, 10 (05) :728-753
[8]   Dielectrophoresis-based sample handling in general-purpose programmable diagnostic instruments [J].
Gascoyne, PRC ;
Vykoukal, JV .
PROCEEDINGS OF THE IEEE, 2004, 92 (01) :22-42
[9]   Dielectrophoretic separation of cancer cells from blood [J].
Gascoyne, PRC ;
Wang, XB ;
Huang, Y ;
Becker, FF .
IEEE TRANSACTIONS ON INDUSTRY APPLICATIONS, 1997, 33 (03) :670-678
[10]   Dielectric spectroscopy in a micromachined flow cytometer: theoretical and practical considerations [J].
Gawad, S ;
Cheung, K ;
Seger, U ;
Bertsch, A ;
Renaud, P .
LAB ON A CHIP, 2004, 4 (03) :241-251