Vaccine design: emerging concepts and renewed optimism

被引：25

作者：

Grimm, Sebastian K. ^{[1
]}

Ackerman, Margaret E. ^{[1
,2
]}

机构：

[1] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA

[2] Dartmouth Coll, Geisel Sch Med, Dept Microbiol & Immunol, Hanover, NH 03755 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2013年 / 24卷 / 06期

关键词：

VIRUS-LIKE PARTICLES; YELLOW-FEVER VACCINE; ANTIBODY-RESPONSES; IMMUNE-RESPONSES; HUMORAL RESPONSES; MALARIA VACCINE; SYSTEMS BIOLOGY; CELL RESPONSES; HIV-1; INFLUENZA;

D O I：

10.1016/j.copbio.2013.02.015

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Arguably, vaccination represents the single most effective medical intervention ever developed. Yet, vaccines have failed to provide any or adequate protection against some of the most significant global diseases. The pathogens responsible for these vaccine-recalcitrant diseases have properties that allow them to evade immune surveillance and misdirect or eliminate the immune response. However, genomic and systems biology tools, novel adjuvants and delivery systems, and refined molecular insight into protective immunity have started to redefine the landscape, and results from recent efficacy trials of HIV and malaria vaccines have instilled hope that another golden age of vaccines may be on the horizon.

引用

页码：1078 / 1088

页数：11

共 87 条

[1]

Administration FaD, 2010, SERV USDOHAH

[2] First Results of Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Children [J].

Agnandji, Selidji Todagbe ;

Lell, Bertrand ;

Soulanoudjingar, Solange Solmeheim ;

Fernandes, Jose Francisco ;

Abossolo, Beatrice Peggy ;

Conzelmann, Cornelia ;

Methogo, Barbara Gaelle Nfono Ondo ;

Doucka, Yannick ;

Flamen, Arnaud ;

Mordmueller, Benjamin ;

Issifou, Saadou ;

Kremsner, Peter Gottfried ;

Sacarlal, Jahit ;

Aide, Pedro ;

Lanaspa, Miguel ;

Aponte, John J. ;

Nhamuave, Arlindo ;

Quelhas, Diana ;

Bassat, Quique ;

Mandjate, Sofia ;

Macete, Eusebio ;

Alonso, Pedro ;

Abdulla, Salim ;

Salim, Nahya ;

Juma, Omar ;

Shomari, Mwanajaa ;

Shubis, Kafuruki ;

Machera, Francisca ;

Hamad, Ali Said ;

Minja, Rose ;

Mpina, Maxmillian ;

Mtoro, Ali ;

Sykes, Alma ;

Ahmed, Saumu ;

Urassa, Alwisa Martin ;

Ali, Ali Mohammed ;

Mwangoka, Grace ;

Tanner, Marcel ;

Tinto, Halidou ;

D'Alessandro, Umberto ;

Sorgho, Hermann ;

Valea, Innocent ;

Tahita, Marc Christian ;

Kabore, William ;

Ouedraogo, Sayouba ;

Sandrine, Yara ;

Guiguemde, Robert Tinga ;

Ouedraogo, Jean Bosco ;

Hamel, Mary J. ;

Kariuki, Simon .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (20) :1863-1875

[3] Ranking viruses: measures of positional importance within networks define core viruses for rational polyvalent vaccine development [J].

Anderson, Tavis K. ;

Laegreid, William W. ;

Cerutti, Francesco ;

Osorio, Fernando A. ;

Nelson, Eric A. ;

Christopher-Hennings, Jane ;

Goldberg, Tony L. .

BIOINFORMATICS, 2012, 28 (12) :1624-1632

[4] Safety and efficacy of the RTS,S/AS01E candidate malaria vaccine given with expanded-programme-on-immunisation vaccines: 19 month follow-up of a randomised, open-label, phase 2 trial [J].

Asante, Kwaku Poku ;

Abdulla, Salim ;

Agnandji, Selidji ;

Lyimo, John ;

Vekemans, Johan ;

Soulanoudjingar, Solange ;

Owusu, Ruth ;

Shomari, Mwanajaa ;

Leach, Amanda ;

Jongert, Erik ;

Salim, Nahya ;

Fernandes, Jose F. ;

Dosoo, David ;

Chikawe, Maria ;

Issifou, Saadou ;

Osei-Kwakye, Kingsley ;

Lievens, Marc ;

Paricek, Maria ;

Moeller, Tina ;

Apanga, Stephen ;

Mwangoka, Grace ;

Dubois, Marie-Claude ;

Madi, Tigani ;

Kwara, Evans ;

Minja, Rose ;

Hounkpatin, Aurore B. ;

Boahen, Owusu ;

Kayan, Kingsley ;

Adjei, George ;

Chandramohan, Daniel ;

Carter, Terrell ;

Vansadia, Preeti ;

Sillman, Marla ;

Savarese, Barbara ;

Loucq, Christian ;

Lapierre, Didier ;

Greenwood, Brian ;

Cohen, Joe ;

Kremsner, Peter ;

Owusu-Agyei, Seth ;

Tanner, Marcel ;

Lell, Bertrand .

LANCET INFECTIOUS DISEASES, 2011, 11 (10) :741-749

[5] Antibody-Mediated Protection against Mucosal Simian-Human Immunodeficiency Virus Challenge of Macaques Immunized with Alphavirus Replicon Particles and Boosted with Trimeric Envelope Glycoprotein in MF59 Adjuvant [J].

Barnett, Susan W. ;

Burke, Brian ;

Sun, Yide ;

Kan, Elaine ;

Legg, Harold ;

Lian, Ying ;

Bost, Kristen ;

Zhou, Fengmin ;

Goodsell, Amanda ;

zur Megede, Jan ;

Polo, John ;

Donnelly, John ;

Ulmer, Jeffrey ;

Otten, Gillis R. ;

Miller, Christopher J. ;

Vajdy, Michael ;

Srivastava, Indresh K. .

JOURNAL OF VIROLOGY, 2010, 84 (12) :5975-5985

[6] Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys [J].

Barouch, Dan H. ;

Liu, Jinyan ;

Li, Hualin ;

Maxfield, Lori F. ;

Abbink, Peter ;

Lynch, Diana M. ;

Iampietro, M. Justin ;

SanMiguel, Adam ;

Seaman, Michael S. ;

Ferrari, Guido ;

Forthal, Donald N. ;

Ourmanov, Ilnour ;

Hirsch, Vanessa M. ;

Carville, Angela ;

Mansfield, Keith G. ;

Stablein, Donald ;

Pau, Maria G. ;

Schuitemaker, Hanneke ;

Sadoff, Jerald C. ;

Billings, Erik A. ;

Rao, Mangala ;

Robb, Merlin L. ;

Kim, Jerome H. ;

Marovich, Mary A. ;

Goudsmit, Jaap ;

Michael, Nelson L. .

NATURE, 2012, 482 (7383) :89-U115

[7] Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys [J].

Barouch, Dan H. ;

O'Brien, Kara L. ;

Simmons, Nathaniel L. ;

King, Sharon L. ;

Abbink, Peter ;

Maxfield, Lori F. ;

Sun, Ying-Hua ;

La Porte, Annalena ;

Riggs, Ambryice M. ;

Lynch, Diana M. ;

Clark, Sarah L. ;

Backus, Katherine ;

Perry, James R. ;

Seaman, Michael S. ;

Carville, Angela ;

Mansfield, Keith G. ;

Szinger, James J. ;

Fischer, Will ;

Muldoon, Mark ;

Korber, Bette .

NATURE MEDICINE, 2010, 16 (03) :319-U116

[8] A Meningococcal Factor H Binding Protein Mutant That Eliminates Factor H Binding Enhances Protective Antibody Responses to Vaccination [J].

Beernink, Peter T. ;

Shaughnessy, Jutamas ;

Braga, Emily M. ;

Liu, Qin ;

Rice, Peter A. ;

Ram, Sanjay ;

Granoff, Dan M. .

JOURNAL OF IMMUNOLOGY, 2011, 186 (06) :3606-3614

[9] Design of an HA2-based Escherichia coli expressed influenza immunogen that protects mice from pathogenic challenge [J].

Bommakanti, Gayathri ;

Citron, Michael P. ;

Hepler, Robert W. ;

Callahan, Cheryl ;

Heidecker, Gwendolyn J. ;

Najar, Tariq Ahmad ;

Lu, Xianghan ;

Joyce, Joseph G. ;

Shiver, John W. ;

Casimiro, Danilo R. ;

ter Meulen, Jan ;

Liang, Xiaoping ;

Varadarajan, Raghavan .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (31) :13701-13706

[10] Scaffolding to build a rational vaccine design strategy [J].

Burton, Dennis R. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (42) :17859-17860

← 1 2 3 4 5 6 7 8 9 →