Microfluidic Technology for Nucleic Acid Aptamer Evolution and Application

被引：24

作者：

Fraser, Lewis A. ^{[1
]}

Cheung, Yee-Wai ^{[1
]}

Kinghorn, Andrew B. ^{[1
]}

Guo, Wei ^{[2
]}

Shiu, Simon Chi-Chin ^{[1
]}

Jinata, Chandra ^{[1
]}

Liu, Mengping ^{[1
]}

Bhuyan, Soubhagya ^{[1
]}

Nan, Lang ^{[2
]}

Shum, Ho Cheung ^{[2
]}

Tanner, Julian A. ^{[1
]}

机构：

[1] Univ Hong Kong, LKS Fac Med, Sch Biomed Sci, Hong Kong, Peoples R China

[2] Univ Hong Kong, Fac Engn, Dept Mech Engn, Hong Kong, Peoples R China

来源：

ADVANCED BIOSYSTEMS | 2019年 / 3卷 / 05期

关键词：

aptamers; biosensors; microfluidics; selection; SELEX; CIRCULATING TUMOR-CELLS; IN-VITRO SELECTION; NONEQUILIBRIUM CAPILLARY-ELECTROPHORESIS; VISUAL QUANTITATIVE DETECTION; TARGET-RESPONSIVE HYDROGEL; TETHERED ENZYME CAPTURE; HIGH-THROUGHPUT; CANCER-CELLS; DNA APTAMERS; ELECTROCHEMICAL DETECTION;

D O I：

10.1002/adbi.201900012

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

The intersection of microfluidics and aptamer technologies holds particular promise for rapid progress in a plethora of applications across biomedical science and other areas. Here, the influence of microfluidics on the field of aptamers, from traditional capillary electrophoresis approaches through innovative modern-day approaches using micromagnetic beads and emulsion droplets, is reviewed. Miniaturizing aptamer-based bioassays through microfluidics has the potential to transform diagnostics and embedded biosensing in the coming years.

引用

页数：16

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