Microfluidic Technology for Nucleic Acid Aptamer Evolution and Application

被引：23
|
作者：
Fraser, Lewis A. [1 ]
Cheung, Yee-Wai [1 ]
Kinghorn, Andrew B. [1 ]
Guo, Wei [2 ]
Shiu, Simon Chi-Chin [1 ]
Jinata, Chandra [1 ]
Liu, Mengping [1 ]
Bhuyan, Soubhagya [1 ]
Nan, Lang [2 ]
Shum, Ho Cheung [2 ]
Tanner, Julian A. [1 ]
机构：
[1] Univ Hong Kong, LKS Fac Med, Sch Biomed Sci, Hong Kong, Peoples R China
[2] Univ Hong Kong, Fac Engn, Dept Mech Engn, Hong Kong, Peoples R China
来源：
ADVANCED BIOSYSTEMS | 2019年 / 3卷 / 05期
关键词：
aptamers; biosensors; microfluidics; selection; SELEX; CIRCULATING TUMOR-CELLS; IN-VITRO SELECTION; NONEQUILIBRIUM CAPILLARY-ELECTROPHORESIS; VISUAL QUANTITATIVE DETECTION; TARGET-RESPONSIVE HYDROGEL; TETHERED ENZYME CAPTURE; HIGH-THROUGHPUT; CANCER-CELLS; DNA APTAMERS; ELECTROCHEMICAL DETECTION;
D O I：
10.1002/adbi.201900012
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
The intersection of microfluidics and aptamer technologies holds particular promise for rapid progress in a plethora of applications across biomedical science and other areas. Here, the influence of microfluidics on the field of aptamers, from traditional capillary electrophoresis approaches through innovative modern-day approaches using micromagnetic beads and emulsion droplets, is reviewed. Miniaturizing aptamer-based bioassays through microfluidics has the potential to transform diagnostics and embedded biosensing in the coming years.
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页数：16
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