The multifaceted von Hippel-Lindau tumour suppressor protein

被引：70

作者：

Robinson, Claire M. ^{[1
]}

Ohh, Michael ^{[1
,2
]}

机构：

[1] Univ Toronto, Fac Med, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[2] Univ Toronto, Fac Med, Dept Biochem, Toronto, ON, Canada

来源：

FEBS LETTERS | 2014年 / 588卷 / 16期

基金：

加拿大健康研究院;

关键词：

von Hippel-Lindau protein (pVHL); Clear-cell renal cell carcinoma (ccRCC); Hypoxia-inducible factor (HIF); Epigenetics; BIOLOGICALLY-ACTIVE PRODUCT; HYPOXIA-INDUCIBLE FACTOR-1; ENDOTHELIAL GROWTH-FACTOR; RENAL-CELL CARCINOMA; SOMATIC MUTATIONS; PROLINE HYDROXYLATION; HISTONE DEMETHYLASES; GENE-MUTATIONS; HIF-BINDING; PVHL ACTS;

D O I：

10.1016/j.febslet.2014.02.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Loss of von Hippel-Lindau protein (pVHL) is known to contribute to the initiation and progression of tumours associated with VHL disease as well as certain sporadic tumours including clear cell renal cell carcinoma (ccRCC). The VHL gene was first identified and cloned over 20 years ago and our understanding of its functions and effects has significantly increased since then. The best-known function of pVHL is its role in promoting the degradation of hypoxia-inducible factor a subunit (HIF alpha) as part of an E3 ubiquitin ligase complex. HIF stabilisation and transcriptional activation are also associated with various epigenetic alterations, indicating a potential role for VHL loss with changes in the epigenome. This review will highlight current knowledge regarding pVHL as well as discuss potentially novel roles of pVHL and how these may impact on cancer progression. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2704 / 2711

页数：8

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