The multifaceted von Hippel-Lindau tumour suppressor protein

被引：69

作者：

Robinson, Claire M. ^{[1
]}

Ohh, Michael ^{[1
,2
]}

机构：

[1] Univ Toronto, Fac Med, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[2] Univ Toronto, Fac Med, Dept Biochem, Toronto, ON, Canada

来源：

FEBS LETTERS | 2014年 / 588卷 / 16期

基金：

加拿大健康研究院;

关键词：

von Hippel-Lindau protein (pVHL); Clear-cell renal cell carcinoma (ccRCC); Hypoxia-inducible factor (HIF); Epigenetics; BIOLOGICALLY-ACTIVE PRODUCT; HYPOXIA-INDUCIBLE FACTOR-1; ENDOTHELIAL GROWTH-FACTOR; RENAL-CELL CARCINOMA; SOMATIC MUTATIONS; PROLINE HYDROXYLATION; HISTONE DEMETHYLASES; GENE-MUTATIONS; HIF-BINDING; PVHL ACTS;

D O I：

10.1016/j.febslet.2014.02.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Loss of von Hippel-Lindau protein (pVHL) is known to contribute to the initiation and progression of tumours associated with VHL disease as well as certain sporadic tumours including clear cell renal cell carcinoma (ccRCC). The VHL gene was first identified and cloned over 20 years ago and our understanding of its functions and effects has significantly increased since then. The best-known function of pVHL is its role in promoting the degradation of hypoxia-inducible factor a subunit (HIF alpha) as part of an E3 ubiquitin ligase complex. HIF stabilisation and transcriptional activation are also associated with various epigenetic alterations, indicating a potential role for VHL loss with changes in the epigenome. This review will highlight current knowledge regarding pVHL as well as discuss potentially novel roles of pVHL and how these may impact on cancer progression. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2704 / 2711

页数：8

共 88 条

[1] Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia
Ang, SO
Chen, H
Hirota, K
Gordeuk, VR
Jelinek, J
Guan, YL
Liu, EL
Sergueeva, AI
Miasnikova, GY
Mole, D
Maxwell, PH
Stockton, DW
Semenza, GL
Prchal, JT
[J]. NATURE GENETICS, 2002, 32 (04) : 614 - 621
[2] An essential role for p300/CBP in the cellular response to hypoxia
Arany, Z
Huang, LE
Eckner, R
Bhattacharya, S
Jiang, C
Goldberg, MA
Bunn, HF
Livingston, DM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (23) : 12969 - 12973
[3] Genetics and epigenetics of renal cell cancer
Baldewijns, Marcella M. L.
van Vlodrop, Iris J. H.
Schouten, Leo J.
Soetekouw, Patricia M. M. B.
de Bruine, Adriaan P.
van Engeland, Manon
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2008, 1785 (02): : 133 - 155
[4] The Histone Demethylases JMJD1A and JMJD2B Are Transcriptional Targets of Hypoxia-inducible Factor HIF
Beyer, Sophie
Kristensen, Malene Maag
Jensen, Kim Steen
Johansen, Jens Vilstrup
Staller, Peter
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (52) : 36542 - 36552
[5] Effects of HIF-1 alpha and HIF2 alpha on Growth andMetabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts
Biswas, Swethajit
Troy, Helen
Leek, Russell
Chung, Yuen-Li
Li, Ji-liang
Raval, Raju R.
Turley, Helen
Gatter, Kevin
Pezzella, Francesco
Griffiths, John R.
Stubbs, Marion
Harris, Adrian L.
[J]. JOURNAL OF ONCOLOGY, 2010, 2010
[6] Alternate choice of initiation codon produces a biologically active product of the von Hippel Lindau gene with tumor suppressor activity
Blankenship, C
Naglich, JG
Whaley, JM
Seizinger, B
Kley, N
[J]. ONCOGENE, 1999, 18 (08) : 1529 - 1535
[7] Comprehensivemolecular characterization of clear cell renal cell carcinoma
Creighton, Chad J.
Morgan, Margaret
Gunaratne, Preethi H.
Wheeler, David A.
Gibbs, Richard A.
Robertson, A. Gordon
Chu, Andy
Beroukhim, Rameen
Cibulskis, Kristian
Signoretti, Sabina
Vandin, Fabio
Wu, Hsin-Ta
Raphael, Benjamin J.
Verhaak, Roel G. W.
Tamboli, Pheroze
Torres-Garcia, Wandaliz
Akbani, Rehan
Weinstein, John N.
Reuter, Victor
Hsieh, James J.
Brannon, A. Rose
Hakimi, A. Ari
Jacobsen, Anders
Ciriello, Giovanni
Reva, Boris
Ricketts, Christopher J.
Linehan, W. Marston
Stuart, Joshua M.
Rathmell, W. Kimryn
Shen, Hui
Laird, Peter W.
Muzny, Donna
Davis, Caleb
Morgan, Margaret
Xi, Liu
Chang, Kyle
Kakkar, Nipun
Trevino, Lisa R.
Benton, Susan
Reid, Jeffrey G.
Morton, Donna
Doddapaneni, Harsha
Han, Yi
Lewis, Lora
Dinh, Huyen
Kovar, Christie
Zhu, Yiming
Santibanez, Jireh
Wang, Min
Hale, Walker
[J]. NATURE, 2013, 499 (7456) : 43 - +
[8] Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
Dalgliesh, Gillian L.
Furge, Kyle
Greenman, Chris
Chen, Lina
Bignell, Graham
Butler, Adam
Davies, Helen
Edkins, Sarah
Hardy, Claire
Latimer, Calli
Teague, Jon
Andrews, Jenny
Barthorpe, Syd
Beare, Dave
Buck, Gemma
Campbell, Peter J.
Forbes, Simon
Jia, Mingming
Jones, David
Knott, Henry
Kok, Chai Yin
Lau, King Wai
Leroy, Catherine
Lin, Meng-Lay
McBride, David J.
Maddison, Mark
Maguire, Simon
McLay, Kirsten
Menzies, Andrew
Mironenko, Tatiana
Mulderrig, Lee
Mudie, Laura
O'Meara, Sarah
Pleasance, Erin
Rajasingham, Arjunan
Shepherd, Rebecca
Smith, Raffaella
Stebbings, Lucy
Stephens, Philip
Tang, Gurpreet
Tarpey, Patrick S.
Turrell, Kelly
Dykema, Karl J.
Khoo, Sok Kean
Petillo, David
Wondergem, Bill
Anema, John
Kahnoski, Richard J.
Teh, Bin Tean
Stratton, Michael R.
[J]. NATURE, 2010, 463 (7279) : 360 - 363
[9] C-elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
Epstein, ACR
Gleadle, JM
McNeill, LA
Hewitson, KS
O'Rourke, J
Mole, DR
Mukherji, M
Metzen, E
Wilson, MI
Dhanda, A
Tian, YM
Masson, N
Hamilton, DL
Jaakkola, P
Barstead, R
Hodgkin, J
Maxwell, PH
Pugh, CW
Schofield, CJ
Ratcliffe, PJ
[J]. CELL, 2001, 107 (01) : 43 - 54
[10] Inadequate Activation of the GTPase RhoA Contributes to the Lack of Fibronectin Matrix Assembly in von Hippel-Lindau Protein-defective Renal Cancer Cells
Feijoo-Cuaresma, Monica
Mendez, Fernando
Maqueda, Alfredo
Esteban, Miguel A.
Naranjo-Suarez, Salvador
Castellanos, Maria C.
Hernandez del Cerro, Mercedes
Vazquez, Silvia N.
Garcia-Pardo, Angeles
Landazuri, Manuel O.
Calzada, Maria J.
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (36) : 24982 - 24990

← 1 2 3 4 5 6 7 8 9 →