Prevalence of Fowl Adenovirus Serotype 4 and Co-Infection by Immunosuppressive Viruses in Fowl with Hydropericardium Hepatitis Syndrome in Shandong Province, China

被引:24
作者
Yu, Guanliu [1 ,2 ,3 ]
Lin, Yun [1 ,2 ,3 ]
Dou, Yanguo [1 ,2 ,3 ]
Tang, Yi [1 ,2 ,3 ]
Diao, Youxiang [1 ,2 ,3 ]
机构
[1] Shandong Agr Univ, Coll Anim Sci & Technol, 61 Daizong Rd, Tai An 271018, Shandong, Peoples R China
[2] Shandong Agr Univ, Shandong Prov Key Lab Anim Biotechnol & Dis Contr, 61 Daizong Rd, Tai An 271018, Shandong, Peoples R China
[3] Shandong Agr Univ, Shandong Prov Engn Technol Res Ctr Anim Dis Contr, 61 Daizong Rd, Tai An 271018, Shandong, Peoples R China
来源
VIRUSES-BASEL | 2019年 / 11卷 / 06期
关键词
poultry; fowl adenovirus serotype 4; hydropericardium hepatitis syndrome; epidemiological investigation; immunosuppressive viruses; GIZZARD EROSION; PHYLOGENETIC ANALYSIS; INFECTION; HEXON; CIRCOVIRUS; CHICKENS; DUCKS;
D O I
10.3390/v11060517
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Fowl adenovirus serotype 4 (FAdV-4) is the pathogenic agent of hydropericardium hepatitis syndrome (HHS) in chickens and ducks, which has caused huge economic losses for the Chinese poultry industry since 2015. In order to objectively determine the prevalence and co-infection status of the virus in Shandong province in China, we analyzed a total of 679 clinical cases of chickens and ducks from 36 farms in the province. The results showed that the FAdV-4 infection rate was 65.2% (443/679), and the rate in breeder ducks was almost two-fold higher than that in breeder chickens (68.57% vs. 34.30%). Notably, co-infection by H9N2 avian influenza virus, infectious bursal disease virus, and/or chicken infectious anemia virus was very common in the 443 FAdV-4-positive cases. Furthermore, phylogenetic analysis of the hexon genes of four Shandong FAdV-4 isolates revealed that these strains clustered into Indian reference strains, indicating that the Shandong FAdV-4 strains might have originated in India. These findings provide the first data on the prevalence and co-infection status of FAdV-4 in Shandong province, which may serve as a foundation for the prevention of FAdV-4 in the field.
引用
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页数:9
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