Cortisol and estradiol: Nongenetic factors for hyperhomocyst(e)inemia

被引：51
作者：
Kim, MH [1 ]
Kim, E [1 ]
Passen, EL [1 ]
Meyer, J [1 ]
Kang, SS [1 ]
机构：
[1] RUSH MED COLL,DEPT PEDIAT,GENET SECT,CHICAGO,IL 60612
来源：
METABOLISM-CLINICAL AND EXPERIMENTAL | 1997年 / 46卷 / 03期
关键词：
D O I：
10.1016/S0026-0495(97)90248-1
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A low plasma homocyst(e)ine concentration in premenopausal and pregnant women compared with postmenopausal women and men suggests that steroid hormones are nongenetic factors affecting homocysteine metabolism. This hypothesis was tested by determining plasma homocyst(e)ine levels in adult male rats treated with cortisol, estradiol, or a combination of both. Mean plasma homocyst(e)ine concentrations were 3.71 +/- 0.71, 5.26 +/- 1.76, and 4.28 +/- 0.84 nmol/mL in cortisol-treated, estradiol-treated, and cortisol plus estradiol-treated groups, respectively. These values were substantially low compared with the level of 7.32 +/- 0.89 nmol/mL plasma homocyst(e)ine in the control group, indicating a significant effect of steroid hormones on homocysteine metabolism. Copyright (C) 1997 by W.B. Saunders Company.
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页码：247 / 249
页数：3
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