Cholesterol, oxidative stress, and Alzheimer's disease: Expanding the horizons of pathogenesis

被引：72
作者：
Pappolla, MA
Smith, MA
Bryant-Thomas, T
Bazan, N
Petanceska, S
Perry, G
Thal, LJ
Sano, M
Refolo, LM
机构：
[1] Univ S Alabama, Dept Pathol, Mobile, AL 36617 USA
[2] Case Western Reserve Univ, Cleveland, OH 44106 USA
[3] Louisiana State Univ, New Orleans, LA USA
[4] NYU, New York, NY 10012 USA
[5] Nathan S Kline Inst Psychiat Res, New York, NY USA
[6] Univ Calif San Diego, San Diego, CA 92103 USA
[7] Columbia Univ Coll Phys & Surg, New York, NY 10032 USA
[8] Inst Study Aging, New York, NY USA
来源：
FREE RADICAL BIOLOGY AND MEDICINE | 2002年 / 33卷 / 02期
关键词：
Alzheimer's disease; amyloid beta peptide; cholesterol; neurofibrillary tangles; oxidative stress; free radicals; neurodegeneration;
D O I：
10.1016/S0891-5849(02)00841-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent epidemiological, clinical, and experimental data suggest that cholesterol may play a role in Alzheimer's disease (AD). We have recently shown that cholesterolemia has a profound effect in the development and modulation of amyloid pathology in a transgenic model of AD. This review summarizes recent advancements in our understanding of the potential role of cholesterol and the amyloid beta protein in initiating the generation of free radicals and points out their role in a chain of events that causes damage of essential macromolecules in the central nervous system and culminates in neuronal dysfunction and loss. Experimental data links cholesterol and oxidative stress with some neurodegenerative aspects of AD. (C) 2002 Elsevier Science Inc.
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收藏
页码：173 / 181
页数：9
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