Targeting autophagy to overcome drug resistance: further developments

被引:185
作者
Chang, Haocai [1 ,2 ,3 ]
Zou, Zhengzhi [1 ,2 ,3 ]
机构
[1] South China Normal Univ, Coll Biophoton, MOE Key Lab Laser Life Sci, Guangzhou 510631, Peoples R China
[2] South China Normal Univ, Coll Biophoton, Inst Laser Life Sci, Guangzhou 510631, Peoples R China
[3] South China Normal Univ, Coll Biophoton, Guangdong Prov Key Lab Laser Life Sci, 55 Zhongshan Ave West, Guangzhou 510631, Peoples R China
基金
中国国家自然科学基金;
关键词
Autophagy; Drug resistance; Metabolic stress; p53; MAPK; miRNA; Therapeutic antibody; Histone deacetylase; STRESS-INDUCED AUTOPHAGY; APOPTOTIC CELL-DEATH; CANCER-CELLS; MUTANT P53; PROSTATE-CANCER; BREAST-CANCER; DOWN-REGULATION; TUMOR-CELLS; ER-STRESS; MULTIDRUG-RESISTANCE;
D O I
10.1186/s13045-020-01000-2
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Inhibiting cell survival and inducing cell death are the main approaches of tumor therapy. Autophagy plays an important role on intracellular metabolic homeostasis by eliminating dysfunctional or unnecessary proteins and damaged or aged cellular organelles to recycle their constituent metabolites that enable the maintenance of cell survival and genetic stability and even promotes the drug resistance, which severely limits the efficacy of chemotherapeutic drugs. Currently, targeting autophagy has a seemingly contradictory effect to suppress and promote tumor survival, which makes the effect of targeting autophagy on drug resistance more confusing and fuzzier. In the review, we summarize the regulation of autophagy by emerging ways, the action of targeting autophagy on drug resistance and some of the new therapeutic approaches to treat tumor drug resistance by interfering with autophagy-related pathways. The full-scale understanding of the tumor-associated signaling pathways and physiological functions of autophagy will hopefully open new possibilities for the treatment of tumor drug resistance and the improvement in clinical outcomes.
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页数:18
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