Nickel-Catalyzed C-H Alkylations: Direct Secondary Alkylations and Trifluoroethylations of Arenes

被引：239

作者：

Song, Weifeng ^{[1
]}

Lackner, Sebastian ^{[1
]}

Ackermann, Lutz ^{[1
]}

机构：

[1] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 09期

基金：

欧洲研究理事会;

关键词：

auxiliary assistance; C-H activation; nickel; secondary alkylation; trifluoroethylation; UNACTIVATED C(SP(3))-H BONDS; ELECTRON-DEFICIENT ARENES; CROSS-COUPLING REACTIONS; ALKYL-HALIDES; AROMATIC AMIDES; ACID DERIVATIVES; ACTIVATION; FUNCTIONALIZATION; ARYLATION; HYDROHETEROARYLATION;

D O I：

10.1002/anie.201309584

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A versatile nickel catalyst allowed for C-H alkylations of unactivated arenes with challenging secondary alkyl bromides and chlorides. The high catalytic efficacy also set the stage for direct secondary alkylations of indoles as well as C-H trifluoroethylations with ample substrate scope.

引用

页码：2477 / 2480

页数：4

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