Liquid Crystals: An Approach in Drug Delivery

被引：39
作者：
Rajak, P. [1 ]
Nath, L. K. [1 ]
Bhuyan, B. [1 ]
机构：
[1] Dibrugarh Univ, Dept Pharmaceut Sci, Dibrugarh 786004, Assam, India
来源：
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2019年 / 81卷 / 01期
关键词：
Lyotropic liquid crystals; thermotropic liquid crystals; drug delivery; mesophases; cubic phase; WATER-SOLUBLE DRUG; IN-VITRO; SUSTAINED-RELEASE; ORAL DELIVERY; CUBIC PHASE; GLYCERATE SURFACTANTS; AMINO-ACIDS; NANOPARTICLES; SYSTEMS; BIOAVAILABILITY;
D O I：
10.4172/pharmaceutical-sciences.1000474
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Liquid crystal systems are attracting significant attention due to their unique microstructures and physicochemical properties. Liquid crystals are becoming the choicest system for R and D professionals in the formulation development sector. Drug delivery to desired biological targets can effectively be achieved using liquid crystals system. Liquid crystalline phases are formed via three routes, the molecular shape, microsegregation effects and chirality. The objective of the present review was to provide information on different forms of liquid crystal systems along with unique physicochemical properties and possible utilization of the unique physicochemical properties of the systems in pharmaceutical formulation development. This review summarized characterization of liquid crystal mesophases highlighting the multidisciplinary application of liquid crystals in drug delivery with respect to cubic and hexagonal phases.
引用
收藏
页码：11 / 21
页数：11
相关论文
共 50 条
  • [41] Computer-Assisted Drug Formulation Design: Novel Approach in Drug Delivery
    Metwally, Abdelkader A.
    Hathout, Rania M.
    MOLECULAR PHARMACEUTICS, 2015, 12 (08) : 2800 - 2810
  • [42] Silica Nanoparticle Stabilization of Liquid Crystalline Lipid Dispersions: Impact on Enzymatic Digestion and Drug Solubilization
    Bhatt, Achal B.
    Barnes, Timothy J.
    Prestidge, Clive A.
    CURRENT DRUG DELIVERY, 2015, 12 (01) : 47 - 55
  • [43] An Update on the Recent Advances in Cubosome: A Novel Drug Delivery System
    Garg, Madhukar
    Goyal, Anju
    Kumari, Sapna
    CURRENT DRUG METABOLISM, 2021, 22 (06) : 441 - 450
  • [44] Cubic lyotropic liquid crystals as drug delivery carriers: Physicochemical and morphological studies
    Chountoulesi, Maria
    Pippa, Natassa
    Pispas, Stergios
    Chrysina, Evangelia D.
    Forys, Aleksander
    Trzebicka, Barbara
    Demetzos, Costas
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2018, 550 (1-2) : 57 - 70
  • [45] Oil and drug control the release rate from lyotropic liquid crystals
    Martiel, Isabelle
    Baumann, Nicole
    Vallooran, Jijo J.
    Bergfreund, Jotam
    Sagalowicz, Laurent
    Mezzenga, Raffaele
    JOURNAL OF CONTROLLED RELEASE, 2015, 204 : 78 - 84
  • [46] Cyclodextrins in drug delivery systems
    Otero-Espinar, F. J.
    Torres-Labandeira, J. J.
    Alvarez-Lorenzo, C.
    Blanco-Mendez, J.
    JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2010, 20 (04) : 289 - 301
  • [47] CUBIC LIQUID CRYSTALLINE NANOPARTICLES (CUBOSOMES): A NOVEL CARRIER FOR DRUG DELIVERY
    Molly, B. Aubine
    Prasanthi, N. L.
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2019, 10 (03): : 973 - 984
  • [48] Progress in cubic phase of lipid liquid crystal as drug delivery system
    Wang, ZN
    Zheng, LQ
    PROGRESS IN CHEMISTRY, 2005, 17 (03) : 417 - 422
  • [49] Recent Advances in the Development of Liquid Crystalline Nanoparticles as Drug Delivery Systems
    Leu, Jassica S. L.
    Teoh, Jasy J. X.
    Ling, Angel L. Q.
    Chong, Joey
    Loo, Yan Shan
    Azmi, Intan Diana Mat
    Zahid, Noor Idayu
    Bose, Rajendran J. C.
    Madheswaran, Thiagarajan
    PHARMACEUTICS, 2023, 15 (05)
  • [50] Lyotropic Liquid Crystalline Nanostructures as Drug Delivery Systems and Vaccine Platforms
    Chountoulesi, Maria
    Pispas, Stergios
    Tseti, Ioulia K.
    Demetzos, Costas
    PHARMACEUTICALS, 2022, 15 (04)
12345