Synthesis of 1-Adamantyl-3,4,5-R1,R2,R3-Pyrazoles

被引：8

作者：

Butov, G. M. ^{[1
]}

Lysykh, B. A. ^{[1
]}

Dalinger, I. L. ^{[2
]}

Vatsadze, I. A. ^{[2
]}

Shkineva, T. K. ^{[2
]}

Klimochkin, Yu. N. ^{[3
]}

Osyanin, V. A. ^{[3
]}

机构：

[1] Branch Volgograd State Tech Univ, Volzhsky Polytech Inst, Volzhsky 404121, Russia

[2] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Moscow 119991, Russia

[3] Samara State Tech Univ, Samara 443100, Russia

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2014年 / 50卷 / 05期

关键词：

adamantane derivatives; adamantylazoles; adamantylpyrazoles; 1,3-dehydroadamantane; 3,4,5-R-1,R-2,R-3-1H-pyrazoles; 3.3.1]propellanes; adamantylation; NEUROTENSIN RECEPTOR; N-ADAMANTYLATION; PYRAZOLES; AZOLES; ANTAGONIST; 1-(1-ADAMANTYL)PYRAZOLES; DERIVATIVES; CHEMISTRY; POTENT;

D O I：

10.1007/s10593-014-1530-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method has been developed for the synthesis of 1-adamantyl-3,4,5-R-1,R-2,R-3-pyrazoles by the reaction of 1,3-dehydroadamantane with N-unsubstituted 3,4,5-R-1,R-2,R-3-1H-pyrazoles in an inert solvent. The effect of the NH acidity (pK(a)) of the starting 3,4,5-R-1,R-2,R-3-1H-pyrazole on the course of the reaction and the product yields was studied.

引用

页码：752 / 756

页数：5

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