Biomedical Applications of Synthetic, Biodegradable Polymers for the Development of Anti-Infective Strategies

被引：21

作者：

Bertesteanu, Serban ^{[1
,2
]}

Chifiriuc, Mariana Carmen ^{[3
]}

Grumezescu, Alexandru Mihai ^{[4
]}

Printza, Atnanasia G. ^{[5
]}

Marie-Paule, Thill ^{[6
]}

Grumezescu, Valentina ^{[7
]}

Mihaela, Vlad ^{[5
]}

Lazar, Veronica ^{[3
]}

Grigore, Raluca ^{[1
,2
]}

机构：

[1] Carol Davila Univ Med & Pharm, Bucharest, Romania

[2] Coltea Hosp, ENT Clinic, ENT Dept, Bucharest, Romania

[3] Univ Bucharest, Fac Biol, Dept Microbiol, Bucharest 60101, Romania

[4] Univ Politehn Bucuresti, Dept Sci & Engn Oxide Mat & Nanomat, Fac Appl Chem & Mat Sci, Bucharest 011061, Romania

[5] Aristotle Univ Thessaloniki, Sch Med, Thessaloniki, Greece

[6] Ctr Hosp Univ ST PIERRE, B-1000 Brussels, Belgium

[7] Natl Inst Lasers Plasma & Radiat Phys, Lasers Dept, Bucharest, Romania

来源：

CURRENT MEDICINAL CHEMISTRY | 2014年 / 21卷 / 29期

关键词：

Antibiotics; anti-inflammatory; biodegradability; biofilms; devices; drug delivery; microbicidal peptides; synthetic polymers; vaccine; ELASTIN-LIKE POLYPEPTIDE; DRUG-DELIVERY SYSTEMS; IN-VITRO EVALUATION; POLYKETAL MICROPARTICLES; ANTIMICROBIAL POLYMERS; NANOPARTICLES; RELEASE; ANTIBACTERIAL; CELLS; VIVO;

D O I：

10.2174/0929867321666140304104328

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The emergence of antibiotic resistance in microbial strains is representing one of the major threats to public health worldwide, due to the decreased or total cancelling of the available antibiotics effectiveness, correlated with the slow development of novel antibiotics. Due to their excellent biodegradability and biocompatibility, the synthetic polymers could find a lot of biomedical applications, such as the development of biomaterials with optimized properties and of drug delivery systems. This review is focusing on the applications of synthetic, biodegradable polymers for the improvement of antiinfective therapeutic and prophylactic agents (i.e., antimicrobial and anti-inflammatory agents and vaccines) activity, as well as for the design of biomaterials with increased biocompatibility and resistance to microbial colonization.

引用

页码：3383 / 3390

页数：8

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