The Effect of Testosterone on Cardiovascular Disease: A Critical Review of the Literature

被引：13

作者：

Su, Jeannie J. ^{[1
]}

Park, Samuel K. ^{[1
]}

Hsieh, T. Mike ^{[1
]}

机构：

[1] Univ Calif San Diego, San Diego, CA 92103 USA

来源：

AMERICAN JOURNAL OF MENS HEALTH | 2014年 / 8卷 / 06期

关键词：

testosterone; cardiovascular disease; hypogonadism; CORONARY-ARTERY-DISEASE; CHRONIC HEART-FAILURE; HORMONE-BINDING GLOBULIN; ENDOGENOUS SEX-HORMONES; LOW SERUM TESTOSTERONE; INTIMA-MEDIA THICKNESS; MIDDLE-AGED MEN; INDIVIDUAL PARTICIPANT METAANALYSIS; ENDOTHELIAL PROGENITOR CELLS; ANABOLIC-ANDROGENIC STEROIDS;

D O I：

10.1177/1557988314522642

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Cardiovascular disease is the leading cause of death in the United States. Testosterone is the principal male sex hormone and plays an important role in men's health and well-being. Historically, testosterone was believed to adversely affect cardiovascular function. However, contemporary literature has refuted this traditional thinking; testosterone has been suggested to have a protective effect on cardiovascular function through its effects on the vascular system. Data from modern research indicate that hypogonadism is closely related to the development of various cardiovascular risk factors, including hyperlipidemia and insulin resistance. Several studies have demonstrated beneficial effects of testosterone supplementation therapy on reversing symptoms of hypogonadism and improving cardiovascular disease risk profiles. In this review, we perform a critical analysis on the association between testosterone and cardiovascular disease.

引用

页码：470 / 491

页数：22

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