Enhancing the Osteogenic Differentiation and Rapid Osseointegration of 3D Printed Ti6Al4V Implants via Nano-Topographic Modification

被引：33
作者：
Wang, Hui [1 ]
Zhang, Xinran [1 ]
Wang, Haicheng [1 ]
Zhang, Jinkai [1 ]
Li, Jia [1 ]
Ruan, Changshun [2 ]
Zhu, Rui [3 ]
Lin, Kaili [1 ]
机构：
[1] Tongji Univ, Shanghai Engn Res Ctr Tooth Restorat & Regenerat, Sch & Hosp Stomatol, Shanghai 200072, Peoples R China
[2] Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Res Ctr Human Tissue & Organs Degenerat, Shenzhen 518055, Peoples R China
[3] Tongji Univ, Tongji Hosp, Spine Div Orthopaed Dept, Sch Med, Shanghai 200065, Peoples R China
来源：
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | 2018年 / 14卷 / 04期
关键词：
Three-Dimensional Printing; Titanium and Its Alloy; Alkali-Heat-Treatment; Nano-Topography; Osteogenesis; Rapid Osseointegration; MESENCHYMAL STEM-CELLS; VIVO BONE-FORMATION; TITANIUM SURFACES; HYDROXYAPATITE BIOCERAMICS; NANOFIBROUS SCAFFOLD; OSTEOBLAST ADHESION; PROTEIN ADSORPTION; BIOACTIVE IONS; PROMOTE; REGENERATION;
D O I：
10.1166/jbn.2018.2551
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Personalized precision therapy and rapid osseointegration are the main development directions of dental implants. Three-dimensional (3D) printing is the most promising method to fabricate personalized implants with complex design and structure. Rapid osseointegration guarantees the survival of implants especially at early implant time, and the surface modification via nano-technology is considered as the most effective method to promote osseointegration. Herein, the Ti6Al4V implants were fabricated by 3D-printing method then the nano-topographic surface was constructed on them to improve the biological responses. The results showed that the nano-topographic modification favored the adhesion and osteogenic differentiation of bone marrow derived mesenchymal stromal cells (BMSCs), accelerating the rapid osseointegration in vivo in rat condyle of femur model. It is reasonable to predict that 3D-printed implants with nano-topographic surface modification have a promising future in orthopedic applications.
引用
收藏
页码：707 / 715
页数：9
相关论文
共 44 条
  • [1] Early bone formation adjacent to rough and turned endosseous implant surfaces - An experimental study in the dog
    Abrahamsson, I
    Berglundh, T
    Linder, E
    Lang, NP
    Lindhe, J
    [J]. CLINICAL ORAL IMPLANTS RESEARCH, 2004, 15 (04) : 381 - 392
  • [2] Designing of Combined Nano and Microfiber Network by Immobilization of Oxidized Cellulose Nanofiber on Polycaprolactone Fibrous Scaffold
    Amirian, Jhaleh
    Lee, Sun-Young
    Lee, Byong-Taek
    [J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2016, 12 (10) : 1864 - 1875
  • [3] Osteoblast adhesion on biomaterials
    Anselme, K
    [J]. BIOMATERIALS, 2000, 21 (07) : 667 - 681
  • [4] Effect of wettability and surface functional groups on protein adsorption and cell adhesion using well-defined mixed self-assembled monolayers
    Arima, Yusuke
    Iwata, Hiroo
    [J]. BIOMATERIALS, 2007, 28 (20) : 3074 - 3082
  • [5] Osteoblastic and osteoclastic differentiation on SLA and hydrophilic modified SLA titanium surfaces
    Bang, Sung-Moon
    Moon, Ho-Jin
    Kwon, Yong-Dae
    Yoo, Ji-Yeon
    Pae, Ahran
    Kwon, Il Keun
    [J]. CLINICAL ORAL IMPLANTS RESEARCH, 2014, 25 (07) : 831 - 837
  • [6] A nanoporous titanium surface promotes the maturation of focal adhesions and formation of filopodia with distinctive nanoscale protrusions by osteogenic cells
    Bello, Dainelys Guadarrama
    Fouillen, Aurelien
    Badia, Antonella
    Nanci, Antonio
    [J]. ACTA BIOMATERIALIA, 2017, 60 : 339 - 349
  • [7] Effect of surface alkali-based treatment of titanium implants on ability to promote in vitro mineralization and in vivo bone formation
    Camargo, Winston A.
    Takemoto, Shinji
    Hoekstra, Jan Willem
    Leeuwenburgh, Sander C. G.
    Jansen, John A.
    van den Beucken, Jeroen J. J. P.
    Alghamdi, Hamdan S.
    [J]. ACTA BIOMATERIALIA, 2017, 57 : 511 - 523
  • [8] Micron/Submicron Hybrid Topography of Titanium Surfaces Influences Adhesion and Differentiation Behaviors of the Mesenchymal Stem Cells
    Chen, Peng
    Aso, Toshihiro
    Sasaki, Ryuichiro
    Tsutsumi, Yusuke
    Ashida, Maki
    Doi, Hisashi
    Hanawa, Takao
    [J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2017, 13 (03) : 324 - 336
  • [9] Tuning Chemistry and Topography of Nanoengineered Surfaces to Manipulate Immune Response for Bone Regeneration Applications
    Chen, Zetao
    Bachhuka, Akash
    Han, Shengwei
    Wei, Fei
    Lu, Shifeier
    Visalakshan, Rahul Madathiparambil
    Vasilev, Krasimir
    Xiao, Yin
    [J]. ACS NANO, 2017, 11 (05) : 4494 - 4506
  • [10] Calcium Plasma Implanted Titanium Surface with Hierarchical Microstructure for Improving the Bone Formation
    Cheng, Mengqi
    Qiao, Yuqin
    Wang, Qi
    Jin, Guodong
    Qin, Hui
    Zhao, Yaochao
    Peng, Xiaochun
    Zhang, Xianlong
    Liu, Xuanyong
    [J]. ACS APPLIED MATERIALS & INTERFACES, 2015, 7 (23) : 13053 - 13061
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