The Antigen Expressway: Follicular Conduits Carry Antigen to B Cells

被引:14
作者
Harwood, Naomi E. [1 ]
Batista, Facundo D. [1 ]
机构
[1] Canc Res UK London Res Inst, Lincolns Inn Fields Labs, Lymphocyte Interact Lab, London WC2A 3PX, England
关键词
LYMPH-NODE; SUBCAPSULAR SINUS; FOLLICLES; AREA;
D O I
10.1016/j.immuni.2009.01.004
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:177 / 179
页数:3
相关论文
共 10 条
[1]   Follicular dendritic cell networks of primary follicles and germinal centers: Phenotype and function [J].
Allen, Christopher D. C. ;
Cyster, Jason G. .
SEMINARS IN IMMUNOLOGY, 2008, 20 (01) :14-25
[2]   The who, how and where of antigen presentation to B cells [J].
Batista, Facundo D. ;
Harwood, Naomi E. .
NATURE REVIEWS IMMUNOLOGY, 2009, 9 (01) :15-27
[3]   B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus of the lymph node [J].
Carrasco, Yolanda R. ;
Batista, Facundo D. .
IMMUNITY, 2007, 27 (01) :160-171
[4]   Lymph-borne chemokines and other low molecular weight molecules reach high endothelial venules via specialized conduits while a functional barrier limits access to the lymphocyte microenvironments in lymph node cortex [J].
Gretz, JE ;
Norbury, CC ;
Anderson, AO ;
Proudfoot, AEI ;
Shaw, S .
JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (10) :1425-1439
[5]   Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells [J].
Junt, Tobias ;
Moseman, E. Ashley ;
Iannacone, Matteo ;
Massberg, Steffen ;
Lang, Philipp A. ;
Boes, Marianne ;
Fink, Katja ;
Henrickson, Sarah E. ;
Shayakhmetov, Dmitry M. ;
Di Paolo, Nelson C. ;
Van Rooijen, Nico ;
Mempel, Thorsten R. ;
Whelan, Sean P. ;
von Andrian, Ulrich H. .
NATURE, 2007, 450 (7166) :110-+
[6]   ANTIGENS IN IMMUNITY .15. ULTRASTRUCTURAL FEATURES OF ANTIGEN CAPTURE IN PRIMARY AND SECONDARY LYMPHOID FOLLICLES [J].
NOSSAL, GJV ;
ABBOT, A ;
MITCHELL, J ;
LUMMUS, Z .
JOURNAL OF EXPERIMENTAL MEDICINE, 1968, 127 (02) :277-&
[7]   The humoral immune response is initiated in lymph nodes by B cells that acquire soluble antigen directly in the follicles [J].
Pape, Kathryn A. ;
Catron, Drew M. ;
Itano, Andrea A. ;
Jenkins, Marc K. .
IMMUNITY, 2007, 26 (04) :491-502
[8]   Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells [J].
Phan, Tri Giang ;
Grigorova, Irina ;
Okada, Takaharu ;
Cyster, Jason G. .
NATURE IMMUNOLOGY, 2007, 8 (09) :992-1000
[9]   Conduits Mediate Transport of Low-Molecular-Weight Antigen to Lymph Node Follicles [J].
Roozendaal, Ramon ;
Mempel, Thorsten R. ;
Pitcher, Lisa A. ;
Gonzalez, Santiago F. ;
Verschoor, Admar ;
Mebius, Reina E. ;
von Andrian, Ulrich H. ;
Carroll, Michael C. .
IMMUNITY, 2009, 30 (02) :264-276
[10]   The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node [J].
Sixt, M ;
Kanazawa, N ;
Seig, M ;
Samson, T ;
Roos, G ;
Reinhardt, DP ;
Pabst, R ;
Lutz, MB ;
Sorokin, L .
IMMUNITY, 2005, 22 (01) :19-29