Microwave assisted green chemical synthesis of novel spiro[indole-pyrido thiazines]: a system reluctant to be formed under thermal conditions

被引：60
作者：
Dandia, A [1 ]
Arya, K [1 ]
Sati, M [1 ]
Gautam, S [1 ]
机构：
[1] Univ Rajasthan, Dept Chem, Jaipur 302004, Rajasthan, India
来源：
TETRAHEDRON | 2004年 / 60卷 / 24期
关键词：
pyrido thiazine; microwave irradiation;
D O I：
10.1016/j.tet.2004.04.018
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Spiro [3H-indole-3,2'-[4H] pyrido [3,2-e]-1,3-thiazine]-2,4' (1H) diones, a class of previously unknown compound which does not form under conventional conditions, can be prepared by treatment of 'in situ' generated 3-indolylimine derivatives with 2-mercaptonicotinic acid under microwave irradiation in absence of any solvent or solid support in 85-92% yields in 3-8 min. The facile one pot reaction is generalized for a variety of ketones and amines to give pure pyrido [3,2-e] thiazine derivatives, which do not require further purification processes. (C) 2004 Elsevier Ltd. All rights reserved.
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页码：5253 / 5258
页数：6
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