Antibacterial properties of water-soluble gold(I) N-heterocyclic carbene complexes

被引：31
|
作者：
Fernandez, Gabriela A. [1 ]
Vela Gurovic, Maria S. [1 ]
Olivera, Nelda L.
Chopa, Alicia B. [1 ]
Silbestri, Gustavo F. [1 ]
机构：
[1] Univ Natl Sur, Dept Quim, INQUISUR, Bahia Blanca, Buenos Aires, Argentina
来源：
JOURNAL OF INORGANIC BIOCHEMISTRY | 2014年 / 135卷
关键词：
Water-soluble Au(I); N-heterocyclic carbene; Antibacterial; ANTIMICROBIAL ACTIVITY; SILVER; AGENTS; RESISTANCE; TOXICITY; AG(I);
D O I：
10.1016/j.jinorgbio.2014.03.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The antibacterial properties of water-soluble gold(I) complexes [1-methyl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C1), [1-mesityl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C2), [1-(2,6-diisopropyl-phenyl)-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C3) and [1,3-bis(2,6-diisopropyl-4-sodiumsulfonatophenyl)imidazol-2-ylidene]gold(I) chloride (C4) and the respective ligands were assessed by agar diffusion and broth macrodilution methods against Gram-positives Staphylococcus aureus, Enterococcus faecalis and Micrococcus luteus and the Gram-negative bacteria Yersinia ruckeri, Pseudomonas aeruginosa and Escherichia coll. Viability after treatments was determined by direct plate count. The bactericidal activity displayed by C1 and C3 was comparable to that of AgNO3. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码：54 / 57
页数：4
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